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Pharmaceuticals 2010, 3(6), 1949-1965; doi:10.3390/ph3061949
Review

Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions

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Received: 8 April 2010; in revised form: 21 May 2010 / Accepted: 11 June 2010 / Published: 14 June 2010
(This article belongs to the collection Non-Steroidal Anti-Inflammatory Drugs)
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Abstract: The term NSAID refers to structurally diverse chemical compounds that share the ability to inhibit the activity of the prostaglandin (PG) biosynthetic enzymes, the cyclooxygenase (COX) isoforms 1 and 2. The suppression of PG synthesis at sites of inflammation has been regarded as primarily responsible for the beneficial properties of NSAIDs, but several COX-independent effects have been described in recent years. Epidemiological studies indicate that NSAIDs are neuroprotective, although the mechanisms underlying their beneficial effect remain largely unknown. Microglial cells play a major role in brain inflammation and are often viewed as major contributors to the neurodegeneration. Therefore, microglia represent a likely target for NSAIDs within the brain. In the present review, we focused on the direct effects of NSAIDs and selective COX-2 inhibitors on microglial functions and discuss the potential efficacy in controlling brain inflammation.
Keywords: brain; cyclooxygenase; microglia; neuroprotection; NSAIDs; PPAR- γ; transcription factors brain; cyclooxygenase; microglia; neuroprotection; NSAIDs; PPAR- γ; transcription factors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ajmone-Cat, M.A.; Bernardo, A.; Greco, A.; Minghetti, L. Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions. Pharmaceuticals 2010, 3, 1949-1965.

AMA Style

Ajmone-Cat MA, Bernardo A, Greco A, Minghetti L. Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions. Pharmaceuticals. 2010; 3(6):1949-1965.

Chicago/Turabian Style

Ajmone-Cat, Maria Antonietta; Bernardo, Antonietta; Greco, Anita; Minghetti, Luisa. 2010. "Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions." Pharmaceuticals 3, no. 6: 1949-1965.


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