Next Article in Journal
Beyond Genetics—Stratified and Personalised Medicines Using Multiple Parameters
Next Article in Special Issue
NSAIDs: Old Drugs Reveal New Anticancer Targets
Previous Article in Journal / Special Issue
NSAIDs, Mitochondria and Calcium Signaling: Special Focus on Aspirin/Salicylates
Article Menu

Export Article

Open AccessReview
Pharmaceuticals 2010, 3(5), 1614-1636; doi:10.3390/ph3051614

Molecular Mechanism for Various Pharmacological Activities of NSAIDS

Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan
Received: 10 December 2009 / Revised: 29 April 2010 / Accepted: 11 May 2010 / Published: 25 May 2010
(This article belongs to the Collection Non-Steroidal Anti-Inflammatory Drugs)
View Full-Text   |   Download PDF [543 KB, uploaded 25 May 2010]   |  

Abstract

The anti-inflammatory action of non-steroidal anti-inflammatory drugs (NSAIDs) is mediated through their inhibitory effects on cyclooxygenase (COX) activity. On the other hand, NSAID use is often associated with gastrointestinal complications. The inhibition of COX by NSAIDs is not the sole explanation for the gastrointestinal side effects of NSAIDs. Furthermore, recent epidemiological studies have revealed that prolonged NSAID use reduces the risk of cancer and Alzheimer’s disease (AD) and a COX-independent unknown mechanism is suggested to be involved in these activities of NSAIDs. In this article, I review our recent work on the COX-independent mechanism involved in NSAID-induced gastric lesions and anti-tumor and anti-AD activities of NSAIDs. Using DNA microarray analysis, we found that NSAIDs affect expression of various genes in a COX-independent manner. We found that membrane permeabilization activity of NSAIDs and resulting NSAID-induced apoptosis are involved in NSAID-induced gastric lesions. On the other hand, induction of expression of tight junction-related genes and endoplasmic reticulum chaperones were suggested to be involved in anti-tumor and anti-AD, respectively, activities of NSAIDs. These results suggest that NSAIDs affect expression of various genes in a COX-independent manner, which is involved in various pharmacological activities of NSAIDs. View Full-Text
Keywords: NSAIDs; gastric ulcer; gene expression; cancer; Alzheimer’s disease NSAIDs; gastric ulcer; gene expression; cancer; Alzheimer’s disease
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mizushima, T. Molecular Mechanism for Various Pharmacological Activities of NSAIDS. Pharmaceuticals 2010, 3, 1614-1636.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top