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Malaria Prophylaxis: A Comprehensive Review
Institute for Infectious and Tropical Diseases, University of Brescia, Piazza Spedali Civili, 1 - 25123–Brescia, Italy
Institute for Infectious Diseases, University of Catania, Via Palermo 635 – 95100 Catania, Italy
* Author to whom correspondence should be addressed.
Received: 1 September 2010; in revised form: 7 October 2010 / Accepted: 11 October 2010 / Published: 13 October 2010
Abstract: The flow of international travellers to and from malaria-endemic areas, especially Africa, has increased in recent years. Apart from the very high morbidity and mortality burden imposed on malaria-endemic areas, imported malaria is the main cause of fever possibly causing severe disease and death in travellers coming from tropical and subtropical areas, particularly Sub-Saharan Africa. The importance of behavioural preventive measures (bed nets, repellents, etc.), adequate chemoprophylaxis and, in selected circumstances, stand-by emergency treatment may not be overemphasized. However, no prophylactic regimen may offer complete protection. Expert advice is needed to tailor prophylactic advice according to traveller (age, baseline clinical conditions, etc.) and travel (destination, season, etc.) characteristics in order to reduce malaria risk.
Keywords: malaria; prophylaxis; traveller
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Castelli, F.; Odolini, S.; Autino, B.; Foca, E.; Russo, R. Malaria Prophylaxis: A Comprehensive Review. Pharmaceuticals 2010, 3, 3212-3239.
Castelli F, Odolini S, Autino B, Foca E, Russo R. Malaria Prophylaxis: A Comprehensive Review. Pharmaceuticals. 2010; 3(10):3212-3239.
Castelli, Francesco; Odolini, Silvia; Autino, Beatrice; Foca, Emanuele; Russo, Rosario. 2010. "Malaria Prophylaxis: A Comprehensive Review." Pharmaceuticals 3, no. 10: 3212-3239.