The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage

doi:10.3390/ph3103186

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Pharmaceuticals 2010, 3(10), 3186-3199; doi:10.3390/ph3103186

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The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage

George Kwok Chu Wong* and Wai Sang Poon

Department of Surgery, Prince of Wales Hospital, Shatin, NT, Hong Kong, China

* Author to whom correspondence should be addressed.

Received: 30 August 2010; in revised form: 29 September 2010 / Accepted: 11 October 2010 / Published: 12 October 2010

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Abstract: Aneurysmal subarachnoid hemorrhage (SAH) has the highest morbidity and mortality rates of all types of stroke. Many aneurysmal SAH patients continue to suffer from significant neurological morbidity and mortality directly related to delayed cerebral ischemia. Pilot clinical studies of the use of Hydroxymethylglutaryl-CoA Reductase Inhibitors (statins) in aneurysmal SAH patients have reported a reduction in delayed cerebral ischemia and better clinical outcomes. We review the biochemical effects of statins on endothelium vascular function, glutamate-mediated neurotoxicity, inflammatory changes, and oxidative injuries, with reference to their possible neuroprotective effects in aneurysmal SAH.

Keywords: aneurysm; hydroxymethylglutaryl-CoA reductase inhibitors; neuroprotective agent; subarachnoid hemorrhage

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MDPI and ACS Style

Wong, G.K.C.; Poon, W.S. The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage. Pharmaceuticals 2010, 3, 3186-3199.

AMA Style

Wong GKC, Poon WS. The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage. Pharmaceuticals. 2010; 3(10):3186-3199.

Chicago/Turabian Style

Wong, George Kwok Chu; Poon, Wai Sang. 2010. "The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage." Pharmaceuticals 3, no. 10: 3186-3199.

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