Next Article in Journal
Endocannabinoids and Human Sperm Cells
Previous Article in Journal
Dual Allosteric Effect in Glycine/NMDA Receptor Antagonism: A Comparative QSAR Approach
Pharmaceuticals 2010, 3(10), 3186-3199; doi:10.3390/ph3103186
Review

The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage

*  and
Received: 30 August 2010 / Revised: 29 September 2010 / Accepted: 11 October 2010 / Published: 12 October 2010
View Full-Text   |   Download PDF [279 KB, uploaded 12 October 2010]   |   Browse Figures

Abstract

Aneurysmal subarachnoid hemorrhage (SAH) has the highest morbidity and mortality rates of all types of stroke. Many aneurysmal SAH patients continue to suffer from significant neurological morbidity and mortality directly related to delayed cerebral ischemia. Pilot clinical studies of the use of Hydroxymethylglutaryl-CoA Reductase Inhibitors (statins) in aneurysmal SAH patients have reported a reduction in delayed cerebral ischemia and better clinical outcomes. We review the biochemical effects of statins on endothelium vascular function, glutamate-mediated neurotoxicity, inflammatory changes, and oxidative injuries, with reference to their possible neuroprotective effects in aneurysmal SAH.
Keywords: aneurysm; hydroxymethylglutaryl-CoA reductase inhibitors; neuroprotective agent; subarachnoid hemorrhage aneurysm; hydroxymethylglutaryl-CoA reductase inhibitors; neuroprotective agent; subarachnoid hemorrhage
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Wong, G.K.C.; Poon, W.S. The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage. Pharmaceuticals 2010, 3, 3186-3199.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert