Pharmaceuticals 2010, 3(10), 3186-3199; doi:10.3390/ph3103186
Review

The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage

Received: 30 August 2010; in revised form: 29 September 2010 / Accepted: 11 October 2010 / Published: 12 October 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Aneurysmal subarachnoid hemorrhage (SAH) has the highest morbidity and mortality rates of all types of stroke. Many aneurysmal SAH patients continue to suffer from significant neurological morbidity and mortality directly related to delayed cerebral ischemia. Pilot clinical studies of the use of Hydroxymethylglutaryl-CoA Reductase Inhibitors (statins) in aneurysmal SAH patients have reported a reduction in delayed cerebral ischemia and better clinical outcomes. We review the biochemical effects of statins on endothelium vascular function, glutamate-mediated neurotoxicity, inflammatory changes, and oxidative injuries, with reference to their possible neuroprotective effects in aneurysmal SAH.
Keywords: aneurysm; hydroxymethylglutaryl-CoA reductase inhibitors; neuroprotective agent; subarachnoid hemorrhage
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MDPI and ACS Style

Wong, G.K.C.; Poon, W.S. The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage. Pharmaceuticals 2010, 3, 3186-3199.

AMA Style

Wong GKC, Poon WS. The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage. Pharmaceuticals. 2010; 3(10):3186-3199.

Chicago/Turabian Style

Wong, George Kwok Chu; Poon, Wai Sang. 2010. "The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage." Pharmaceuticals 3, no. 10: 3186-3199.

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