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Pharmaceuticals 2010, 3(10), 3186-3199; doi:10.3390/ph3103186

The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage

Department of Surgery, Prince of Wales Hospital, Shatin, NT, Hong Kong, China
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Received: 30 August 2010 / Revised: 29 September 2010 / Accepted: 11 October 2010 / Published: 12 October 2010
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Abstract

Aneurysmal subarachnoid hemorrhage (SAH) has the highest morbidity and mortality rates of all types of stroke. Many aneurysmal SAH patients continue to suffer from significant neurological morbidity and mortality directly related to delayed cerebral ischemia. Pilot clinical studies of the use of Hydroxymethylglutaryl-CoA Reductase Inhibitors (statins) in aneurysmal SAH patients have reported a reduction in delayed cerebral ischemia and better clinical outcomes. We review the biochemical effects of statins on endothelium vascular function, glutamate-mediated neurotoxicity, inflammatory changes, and oxidative injuries, with reference to their possible neuroprotective effects in aneurysmal SAH.
Keywords: aneurysm; hydroxymethylglutaryl-CoA reductase inhibitors; neuroprotective agent; subarachnoid hemorrhage aneurysm; hydroxymethylglutaryl-CoA reductase inhibitors; neuroprotective agent; subarachnoid hemorrhage
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wong, G.K.C.; Poon, W.S. The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage. Pharmaceuticals 2010, 3, 3186-3199.

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