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Pharmaceuticals 2010, 3(1), 158-187; doi:10.3390/ph3010158
Review

Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease

1,2,3,* , 4, 5, 6, 2, 7, 3, 8 and 9
Received: 28 November 2009; in revised form: 11 January 2010 / Accepted: 14 January 2010 / Published: 19 January 2010
(This article belongs to the Special Issue Mitochondrial Drugs for Neurodegenerative Diseases)
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Abstract: Mitochondrial dysfunction may be a principal underlying event in aging, including age-associated brain degeneration. Mitochondria provide energy for basic metabolic processes. Their decay with age impairs cellular metabolism and leads to a decline of cellular function. Alzheimer disease (AD) and cerebrovascular accidents (CVAs) are two leading causes of age-related dementia. Increasing evidence strongly supports the theory that oxidative stress, largely due to reactive oxygen species (ROS), induces mitochondrial damage, which arises from chronic hypoperfusion and is primarily responsible for the pathogenesis that underlies both disease processes. Mitochondrial membrane potential, respiratory control ratios and cellular oxygen consumption decline with age and correlate with increased oxidant production. The sustained hypoperfusion and oxidative stress in brain tissues can stimulate the expression of nitric oxide synthases (NOSs) and brain endothelium probably increase the accumulation of oxidative stress products, which therefore contributes to blood brain barrier (BBB) breakdown and brain parenchymal cell damage. Determining the mechanisms behind these imbalances may provide crucial information in the development of new, more effective therapies for stroke and AD patients in the near future.
Keywords: oxidative stress; Alzheimer disease; antioxidants; hypometabolism; mitochondria; metabolism; neurodegeneration oxidative stress; Alzheimer disease; antioxidants; hypometabolism; mitochondria; metabolism; neurodegeneration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Aliev, G.; Palacios, H.H.; Gasimov, E.; Obrenovich, M.E.; Morales, L.; Leszek, J.; Bragin, V.; Solís Herrera, A.; Gokhman, D. Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease. Pharmaceuticals 2010, 3, 158-187.

AMA Style

Aliev G, Palacios HH, Gasimov E, Obrenovich ME, Morales L, Leszek J, Bragin V, Solís Herrera A, Gokhman D. Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease. Pharmaceuticals. 2010; 3(1):158-187.

Chicago/Turabian Style

Aliev, Gjumrakch; Palacios, Hector H.; Gasimov, Eldar; Obrenovich, Mark E.; Morales, Ludis; Leszek, Jerzy; Bragin, Valentin; Solís Herrera, Arturo; Gokhman, Dmitry. 2010. "Oxidative Stress Induced Mitochondrial Failure and Vascular Hypoperfusion as a Key Initiator for the Development of Alzheimer Disease." Pharmaceuticals 3, no. 1: 158-187.



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