Next Article in Journal
Real Time Imaging of Biomarkers in the Parkinson's Brain Using Mini-Implantable Biosensors. II. Pharmaceutical Therapy with Bromocriptine
Next Article in Special Issue
Artesunate: The Best Drug in the Treatment of Severe and Complicated Malaria
Previous Article in Journal
The Soluble Epoxide Hydrolase Inhibitor AR9281 Decreases Blood Pressure, Ameliorates Renal Injury and Improves Vascular Function in Hypertension
Article Menu

Export Article

Open AccessArticle
Pharmaceuticals 2009, 2(3), 228-235; doi:10.3390/ph2030228

Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine

1
Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, MD, USA
2
Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Baltimore, MD 21205, USA
3
Division of Clinical Pharmacology, Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
*
Author to whom correspondence should be addressed.
Received: 24 November 2009 / Revised: 8 December 2009 / Accepted: 18 December 2009 / Published: 21 December 2009
(This article belongs to the Special Issue New Antimalarial Drugs)
View Full-Text   |   Download PDF [150 KB, uploaded 21 December 2009]   |  

Abstract

Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malariainfected mice at a single oral dose of only 8 mg/kg combined with 24 mg/kg of mefloquine hydrochloride. The high efficacy of this ACT chemotherapy is considerably better than the efficacy using the popular trioxane drug artemether plus mefloquine hydrochloride.
Keywords: silylamide trioxanes; antimalarial monomers and dimmers; single dose oral cure silylamide trioxanes; antimalarial monomers and dimmers; single dose oral cure
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Woodard, L.E.; Mott, B.T.; Singhal, V.; Kumar, N.; Shapiro, T.A.; Posner, G.H. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine. Pharmaceuticals 2009, 2, 228-235.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top