Pharmaceuticals 2009, 2(3), 228-235; doi:10.3390/ph2030228
Article

Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine

Lauren E. Woodard 1 email, Bryan T. Mott 1 email, Vandana Singhal 2 email, Nirbhay Kumar 2 email, Theresa A. Shapiro 2,3 email and Gary H. Posner 1,2,* email
1 Department of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218-2685, MD, USA 2 Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Baltimore, MD 21205, USA 3 Division of Clinical Pharmacology, Department of Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
* Author to whom correspondence should be addressed.
Received: 24 November 2009; in revised form: 8 December 2009 / Accepted: 18 December 2009 / Published: 21 December 2009
(This article belongs to the Special Issue New Antimalarial Drugs)
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Abstract: Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malariainfected mice at a single oral dose of only 8 mg/kg combined with 24 mg/kg of mefloquine hydrochloride. The high efficacy of this ACT chemotherapy is considerably better than the efficacy using the popular trioxane drug artemether plus mefloquine hydrochloride.
Keywords: silylamide trioxanes; antimalarial monomers and dimmers; single dose oral cure

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Cite This Article

MDPI and ACS Style

Woodard, L.E.; Mott, B.T.; Singhal, V.; Kumar, N.; Shapiro, T.A.; Posner, G.H. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine. Pharmaceuticals 2009, 2, 228-235.

AMA Style

Woodard LE, Mott BT, Singhal V, Kumar N, Shapiro TA, Posner GH. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine. Pharmaceuticals. 2009; 2(3):228-235.

Chicago/Turabian Style

Woodard, Lauren E.; Mott, Bryan T.; Singhal, Vandana; Kumar, Nirbhay; Shapiro, Theresa A.; Posner, Gary H. 2009. "Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine." Pharmaceuticals 2, no. 3: 228-235.

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