Pharmaceuticals 2009, 2(3), 228-235; doi:10.3390/ph2030228
Article

Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine

1email, 1email, 2email, 2email, 2,3email and 1,2,* email
Received: 24 November 2009; in revised form: 8 December 2009 / Accepted: 18 December 2009 / Published: 21 December 2009
(This article belongs to the Special Issue New Antimalarial Drugs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Three thermally and hydrolytically stable silylamide trioxanes have been prepared from the natural trioxane artemisinin in only five simple chemical steps and in at least 56% overall yield. Two of these new chemical entities completely cured malariainfected mice at a single oral dose of only 8 mg/kg combined with 24 mg/kg of mefloquine hydrochloride. The high efficacy of this ACT chemotherapy is considerably better than the efficacy using the popular trioxane drug artemether plus mefloquine hydrochloride.
Keywords: silylamide trioxanes; antimalarial monomers and dimmers; single dose oral cure
PDF Full-text Download PDF Full-Text [150 KB, uploaded 21 December 2009 09:18 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Woodard, L.E.; Mott, B.T.; Singhal, V.; Kumar, N.; Shapiro, T.A.; Posner, G.H. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine. Pharmaceuticals 2009, 2, 228-235.

AMA Style

Woodard LE, Mott BT, Singhal V, Kumar N, Shapiro TA, Posner GH. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine. Pharmaceuticals. 2009; 2(3):228-235.

Chicago/Turabian Style

Woodard, Lauren E.; Mott, Bryan T.; Singhal, Vandana; Kumar, Nirbhay; Shapiro, Theresa A.; Posner, Gary H. 2009. "Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine." Pharmaceuticals 2, no. 3: 228-235.

Pharmaceuticals EISSN 1424-8247 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert