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Pharmaceuticals 2017, 10(4), 84; doi:10.3390/ph10040084

Acorenone B: AChE and BChE Inhibitor as a Major Compound of the Essential Oil Distilled from the Ecuadorian Species Niphogeton dissecta (Benth.) J.F. Macbr

1
Department of Chemistry and Exact Sciences, Private Technical University of Loja (UTPL), Calle Marcelino Champagnat s/n, 1101608 Loja, Ecuador
2
IRCM, Cancer Research Institute of Montpellier, INSERM, U1194, 34298 Montpellier, France
3
Montpellier Regional Cancer Institute, 34298 Montpellier, France
4
Institut de Recherche en Cancérologie de Montpellier, INSERM, U1194, University of Montpellier, 34298 Montpellier, France
5
Department of Medicine Science and Technology, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy
*
Author to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 24 October 2017 / Accepted: 25 October 2017 / Published: 31 October 2017
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Abstract

This study investigated the chemical composition, physical proprieties, biological activity, and enantiomeric analysis of the essential oil from the aerial parts of Niphogeton dissecta (culantrillo del cerro) from Ecuador, obtained by steam distillation. The qualitative and quantitative analysis of the essential oil was realized by gas chromatographic and spectroscopic techniques (GC-MS and GC-FID). Acorenone B was identified by GC-MS and NMR experiments. The enantiomeric distribution of some constituents has been assessed by enantio-GC through the use of a chiral cyclodextrin-based capillary column. We identified 41 components that accounted for 96.46% of the total analyzed, the major components were acorenone B (41.01%) and (E)-β-ocimene (29.64%). The enantiomeric ratio of (+)/(−)-β-pinene was 86.9:13.1, while the one of (+)/(−)-sabinene was 80.9:19.1. The essential oil showed a weak inhibitory activity, expressed as Minimal Inhibitory Concentration (MIC), against Enterococcus faecalis (MIC 10 mg/mL) and Staphylococcus aureus (MIC 5 mg/mL). Furthermore, it inhibited butyrylcholinesterase with an IC50 value of 11.5 μg/mL. Pure acorenone B showed inhibitory activity against both acetylcholinesterase and butyrylcholinesterase, with IC50 values of 40.8 μg/mL and 10.9 μg/mL, respectively. View Full-Text
Keywords: Niphogeton dissecta; essential oil; enantiomeric distribution; acorenone B; AChE; BChE Niphogeton dissecta; essential oil; enantiomeric distribution; acorenone B; AChE; BChE
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Calva, J.; Bec, N.; Gilardoni, G.; Larroque, C.; Cartuche, L.; Bicchi, C.; Montesinos, J.V. Acorenone B: AChE and BChE Inhibitor as a Major Compound of the Essential Oil Distilled from the Ecuadorian Species Niphogeton dissecta (Benth.) J.F. Macbr. Pharmaceuticals 2017, 10, 84.

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