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Sensors 2009, 9(8), 6254-6260; doi:10.3390/s90806254
Communication

Determination of Glucose Concentration in Aqueous Solution Using ATR-WT-IR Technique

Received: 20 July 2009 / Revised: 30 July 2009 / Accepted: 3 August 2009 / Published: 6 August 2009
(This article belongs to the Section Physical Sensors)
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Abstract

Fourier transformation infrared (FT-IR) spectroscopy has been used to measure glucose concentrations in different matrices. The accuracy of the FT-IR technique does not meet the requirements of medical applications, so we have developed a new, efficient and precise method based on attenuated total reflectance coupled with wavelet transformation (ATR-WT-IR). One thousand interferograms, divided into training- and testing-sets, have been recorded from four glucose concentrations using an ATR-IR unit. Signals were subjected to (WT) and neural network (NN) study in order to design correlation algorithm. The Pearson’s Correlation Coefficient (PCC) obtained by judging the predicted- against the real-concentrations was 0.9954, with a mean square error of 8.4e-005. The proposed ATR-WT-IR method shows efficiency in glucose prediction and could possibly to be integrated into a non-invasive monitoring technique.
Keywords: diabetes; biosensors; glucose monitoring; wavelet; neural network; noninvasive sensing; infrared; ATR diabetes; biosensors; glucose monitoring; wavelet; neural network; noninvasive sensing; infrared; ATR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Al-Gharabli, S.I. Determination of Glucose Concentration in Aqueous Solution Using ATR-WT-IR Technique. Sensors 2009, 9, 6254-6260.

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