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Sensors 2009, 9(8), 6254-6260; doi:10.3390/s90806254

Determination of Glucose Concentration in Aqueous Solution Using ATR-WT-IR Technique

Chemical-Pharmaceutical Engineering Department, School of Applied Medical Sciences, German-Jordanian University, P.O. Box 35247 Amman 11180 Jordan
Received: 20 July 2009 / Revised: 30 July 2009 / Accepted: 3 August 2009 / Published: 6 August 2009
(This article belongs to the Section Chemical Sensors)
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Abstract

Fourier transformation infrared (FT-IR) spectroscopy has been used to measure glucose concentrations in different matrices. The accuracy of the FT-IR technique does not meet the requirements of medical applications, so we have developed a new, efficient and precise method based on attenuated total reflectance coupled with wavelet transformation (ATR-WT-IR). One thousand interferograms, divided into training- and testing-sets, have been recorded from four glucose concentrations using an ATR-IR unit. Signals were subjected to (WT) and neural network (NN) study in order to design correlation algorithm. The Pearson’s Correlation Coefficient (PCC) obtained by judging the predicted- against the real-concentrations was 0.9954, with a mean square error of 8.4e-005. The proposed ATR-WT-IR method shows efficiency in glucose prediction and could possibly to be integrated into a non-invasive monitoring technique.
Keywords: diabetes; biosensors; glucose monitoring; wavelet; neural network; noninvasive sensing; infrared; ATR diabetes; biosensors; glucose monitoring; wavelet; neural network; noninvasive sensing; infrared; ATR
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Al-Gharabli, S.I. Determination of Glucose Concentration in Aqueous Solution Using ATR-WT-IR Technique. Sensors 2009, 9, 6254-6260.

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