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Overview of Electrochemical DNA Biosensors: New Approaches to Detect the Expression of Life
CRIBI Biotechnology Centre and Department of Biology, University of Padova, via U. Bassi 58/B 35121 Padova, Italy
CombiMatrix Corporation, 6500 Harbour Heights Pkwy, 301, Mukilteo, WA 98275, USA
DEIS Dipartimento di Elettronica, Informatica e Sistemistica, University of Bologna, Viale Risorgimento 2, 40136 Bologna, Italy
IBI-EPFL, Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Station 15 CH-1015 Lausanne, Switzerland
* Author to whom correspondence should be addressed.
Received: 18 March 2009; in revised form: 20 April 2009 / Accepted: 23 April 2009 / Published: 24 April 2009
Abstract: DNA microarrays are an important tool with a variety of applications in gene expression studies, genotyping, pharmacogenomics, pathogen classification, drug discovery, sequencing and molecular diagnostics. They are having a strong impact in medical diagnostics for cancer, toxicology and infectious disease applications. A series of papers have been published describing DNA biochips as alternative to conventional microarray platforms to facilitate and ameliorate the signal readout. In this review, we will consider the different methods proposed for biochip construction, focusing on electrochemical detection of DNA. We also introduce a novel single-stranded DNA platform performing high-throughput SNP detection and gene expression profiling.
Keywords: DNA chip; Electrochemical DNA detection; Biosensors; Microarray
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MDPI and ACS Style
Cagnin, S.; Caraballo, M.; Guiducci, C.; Martini, P.; Ross, M.; SantaAna, M.; Danley, D.; West, T.; Lanfranchi, G. Overview of Electrochemical DNA Biosensors: New Approaches to Detect the Expression of Life. Sensors 2009, 9, 3122-3148.
Cagnin S, Caraballo M, Guiducci C, Martini P, Ross M, SantaAna M, Danley D, West T, Lanfranchi G. Overview of Electrochemical DNA Biosensors: New Approaches to Detect the Expression of Life. Sensors. 2009; 9(4):3122-3148.
Cagnin, Stefano; Caraballo, Marcelo; Guiducci, Carlotta; Martini, Paolo; Ross, Marty; SantaAna, Mark; Danley, David; West, Todd; Lanfranchi, Gerolamo. 2009. "Overview of Electrochemical DNA Biosensors: New Approaches to Detect the Expression of Life." Sensors 9, no. 4: 3122-3148.