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Sensors 2008, 8(9), 5229-5237; doi:10.3390/s8095229

Diagnosis of Intoxication by the Organophosphate VX: Comparison Between an Electrochemical Sensor and Ellman´s Photometric Method

Centre of Advanced Studies and Department of Toxicology, Faculty of Military Health Sciences, University of Defense / Trebesska 1575, 50001 Hradec Kralove, Czech Republic
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Received: 22 July 2008 / Revised: 27 August 2008 / Accepted: 28 August 2008 / Published: 1 September 2008
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Abstract

An electrochemical sensor is introduced as a tool applicable for diagnosis of intoxication by cholinesterase inhibitors caused by the well-known nerve agent VX. The traditional Ellman method was chosen for comparison with the sensor's analytical parameters. Both methods are based on estimation of blood cholinesterase inhibition as a marker of intoxication. While Ellman´s method provided a limit of detection of 5.2´10-7 M for blood containing VX, the electrochemical sensor was able to detect 4.0´10-7 M. Good correlation between both methods was observed (R = 0.92). The electrochemical sensor could be considered a convenient tool for a fast yet accurate method, easily available for field as well as laboratory use. Time and cost savings are key features of the sensor-based assay. View Full-Text
Keywords: Organophosphate; carbamate; intoxication; diagnosis; biosensor Organophosphate; carbamate; intoxication; diagnosis; biosensor
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Pohanka, M.; Hrabinova, M.; Kuca, K. Diagnosis of Intoxication by the Organophosphate VX: Comparison Between an Electrochemical Sensor and Ellman´s Photometric Method. Sensors 2008, 8, 5229-5237.

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