Sensors 2008, 8(11), 7113-7124; doi:10.3390/s8117113
Article

Integrated Optic Surface Plasmon Resonance Measurements in a Borosilicate Glass Substrate

1 C.R.E.S., Centro per la Ricerca Elettronica in Sicilia, Via Regione Siciliana 49, 90046 Monreale (PA), Italy 2 DIEET, Dipartimento Ingegneria Elettrica, Elettronica e delle TLC, Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy
* Author to whom correspondence should be addressed.
Received: 9 August 2008; in revised form: 3 November 2008 / Accepted: 7 November 2008 / Published: 11 November 2008
(This article belongs to the Section Biosensors)
PDF Full-text Download PDF Full-Text [806 KB, uploaded 10 November 2008 09:53 CET]
Abstract: The surface plasmon resonance (SPR) technique is a well-known optical method that can be used to measure the refractive index of organic nano-layers adsorbed on a thin metal film. Although there are many configurations for measuring biomolecular interactions, SPR-based techniques play a central role in many current biosensing experiments, since they are the most suited for sensitive and quantitative kinetic measurements. Here we give some results from the analysis and numerical elaboration of SPR data from integrated optics experiments in a particular borosilicate glass, chosen for its composition offering the rather low refractive index of 1.4701 at 633 nm wavelength. These data regard the flow over the sensing region (metal window) of different solutions with refractive indexes in the range of interest (1.3÷1.5) for the detection of contaminants in aqueous solutions. After a discussion of the principles of SPR, of the metal window design optimization by means of optical interaction numerical modeling, and of waveguide fabrication techniques, we give a description of system setup and experimental results. Optimum gold film window thickness and width in this guided-wave configuration has been for the first time derived and implemented on an integrated optic prototype device. Its characterization is given by means of the real time waveguide output intensity measurements, which correspond to the interaction between the sensing gold thin film window and the flowing analyte. The SPR curve was subsequently inferred. Finally, a modified version of the device is reported, with channel waveguides arranged in a Y-junction optical circuit, so that laser source stability requirements are lowered by a factor of 85 dB, making possible the use of low cost sources in practical applications.
Keywords: Biosensors; Integrated Optics; Surface Plasmon Resonance

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Parisi, A.; Cino, A.C.; Busacca, A.C.; Cherchi, M.; Riva-Sanseverino, S. Integrated Optic Surface Plasmon Resonance Measurements in a Borosilicate Glass Substrate. Sensors 2008, 8, 7113-7124.

AMA Style

Parisi A, Cino AC, Busacca AC, Cherchi M, Riva-Sanseverino S. Integrated Optic Surface Plasmon Resonance Measurements in a Borosilicate Glass Substrate. Sensors. 2008; 8(11):7113-7124.

Chicago/Turabian Style

Parisi, Antonino; Cino, Alfonso C.; Busacca, Alessandro C.; Cherchi, Matteo; Riva-Sanseverino, Stefano. 2008. "Integrated Optic Surface Plasmon Resonance Measurements in a Borosilicate Glass Substrate." Sensors 8, no. 11: 7113-7124.

Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert