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Sensors 2006, 6(9), 1139-1152; doi:10.3390/s6091139

Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteine

1
Department of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
2
Subei Hospital, Yangzhou 225002, China
*
Author to whom correspondence should be addressed.
Received: 5 July 2006 / Accepted: 11 August 2006 / Published: 27 September 2006
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Abstract

The improvement of electrochemical detection of meloxicam is presented bymodification of a glassy carbon electrode with anionic layer of cysteic acid providingelectrostatic accumulation of the analyte onto the electrode surface. The modificationformed by electrochemical oxidation of L-cysteine was performed by cycling potential incysteine solution. The anodic peak current obtained at 1.088 V (vs. Ag/AgCl) byvoltammetry was linearly dependent on the meloxicam concentration in the range of 4.3 ×10-8 ~ 8.5 × 10-6 M in the B-R buffer solution (0.04 M, pH 1.86) with a correlationcoefficient of 0.999. The detection limit (S/N = 3) is 1.5 × 10-9 M. The low-cost modifiedelectrode shows good sensitivity, selectivity and stability and has been applied to thedetermination of meloxicam in pharmaceutical formulation and spiked serum withsatisfactory results. The electrochemical reaction mechanism of meloxicam was discussed.
Keywords: cysteic acid; L-cysteine; meloxicam; voltammetry; human serum cysteic acid; L-cysteine; meloxicam; voltammetry; human serum
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, C.Y.; Wang, Z.X.; Guan, J.; Hu, X.Y. Voltammetric Determination of Meloxicam in Pharmaceutical Formulation and Human Serum at Glassy Carbon Electrode Modified by Cysteic Acid Formed by Electrochemical Oxidation of L-cysteine. Sensors 2006, 6, 1139-1152.

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