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Sensors 2006, 6(11), 1523-1536; doi:10.3390/s6111523

Voltammetric Determination of Dopamine in Human Serum with Amphiphilic Chitosan Modified Glassy Carbon Electrode

* ,
Department of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
* Authors to whom correspondence should be addressed.
Received: 14 August 2006 / Accepted: 3 November 2006 / Published: 8 November 2006
(This article belongs to the Special Issue Amperometric Sensors and Techniques for Neurochemical Monitoring)
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An improvement of selectivity for electrochemical detection of dopamine (DA)with differential pulse voltammetry is achieved by covalently modifying a glassy carbonelectrode (GCE) with O-carboxymethylchitosan (OCMCS). The amphiphilic chitosanprovides electrostatic accumulation of DA onto the electrode surface. In a phosphate buffersolution (pH 6.0), a pair of well-defined reversible redox waves of DA was observed at theOCMCS/GCE with a δEp of 52 mV. The anodic peak current obtained from thedifferential pulse voltammetry of dopamine was linearly dependent on its concentration inthe range of 6.0 × 10-8 to 7.0 × 10-6 M, with a correlation coefficient of 0.998. Thedetection limit (S/N = 3) was found to be 1.5 × 10-9 M. The modified electrode had beenapplied to the determination of DA in human serum samples with satisfactory results.
Keywords: O-carboxymethylchitosan; chitosan; dopamine; voltammetry; human serum O-carboxymethylchitosan; chitosan; dopamine; voltammetry; human serum
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, C.Y.; Wang, Z.X.; Zhu, A.P.; Hu, X.Y. Voltammetric Determination of Dopamine in Human Serum with Amphiphilic Chitosan Modified Glassy Carbon Electrode. Sensors 2006, 6, 1523-1536.

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