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Sensors 2006, 6(11), 1523-1536; doi:10.3390/s6111523
Article

Voltammetric Determination of Dopamine in Human Serum with Amphiphilic Chitosan Modified Glassy Carbon Electrode

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Received: 14 August 2006; Accepted: 3 November 2006 / Published: 8 November 2006
(This article belongs to the Special Issue Amperometric Sensors and Techniques for Neurochemical Monitoring)
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Abstract: An improvement of selectivity for electrochemical detection of dopamine (DA)with differential pulse voltammetry is achieved by covalently modifying a glassy carbonelectrode (GCE) with O-carboxymethylchitosan (OCMCS). The amphiphilic chitosanprovides electrostatic accumulation of DA onto the electrode surface. In a phosphate buffersolution (pH 6.0), a pair of well-defined reversible redox waves of DA was observed at theOCMCS/GCE with a δEp of 52 mV. The anodic peak current obtained from thedifferential pulse voltammetry of dopamine was linearly dependent on its concentration inthe range of 6.0 × 10-8 to 7.0 × 10-6 M, with a correlation coefficient of 0.998. Thedetection limit (S/N = 3) was found to be 1.5 × 10-9 M. The modified electrode had beenapplied to the determination of DA in human serum samples with satisfactory results.
Keywords: O-carboxymethylchitosan; chitosan; dopamine; voltammetry; human serum O-carboxymethylchitosan; chitosan; dopamine; voltammetry; human serum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, C.Y.; Wang, Z.X.; Zhu, A.P.; Hu, X.Y. Voltammetric Determination of Dopamine in Human Serum with Amphiphilic Chitosan Modified Glassy Carbon Electrode. Sensors 2006, 6, 1523-1536.

AMA Style

Wang CY, Wang ZX, Zhu AP, Hu XY. Voltammetric Determination of Dopamine in Human Serum with Amphiphilic Chitosan Modified Glassy Carbon Electrode. Sensors. 2006; 6(11):1523-1536.

Chicago/Turabian Style

Wang, Cheng Y.; Wang, Zhi X.; Zhu, Ai P.; Hu, Xiao Y. 2006. "Voltammetric Determination of Dopamine in Human Serum with Amphiphilic Chitosan Modified Glassy Carbon Electrode." Sensors 6, no. 11: 1523-1536.


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