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Sensors 2005, 5(12), 604-612; doi:10.3390/s5120604

Determination of Atropine in Injection with β-Cyclodextrin Modified Ion Sensitive Field Effect Transistor Sensor

1
Chemical Engineering Department, Xi’an Jiaotong University, Xi’an 710049, P.R. China
2
Science School, Guangdong Ocean University, Zhanjiang 524088, P.R. China
*
Author to whom correspondence should be addressed.
Received: 4 March 2005 / Accepted: 19 December 2005 / Published: 21 December 2005
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Abstract

A new atropine drug-FET sensor, which was made of an ISFET (ion sensitivefield effect transistor) and a drug sensitive membrane prepared by adding electric activematter to a β-cyclodextrin solution, was developed. The pH influence, selectivity, responsecurve, reproducibility, stability, response time and life of this sensor were investigated. Apreliminary application of the sensor was discussed as well. The experimental resultsindicated that the sensor showed a Nernst response to atropine with a slope of 58.0mV/decade over the concentration range of 5.0×10-3 - 1.0×10-6 mol/L and the pH rangeof 5.0-8.5. The sensor detection limit was 8.0×10-7 mol/L. The performance of this sensorwas very stable when it was used to determine atropine concentration in a medicinalinjection. The obtained results agreed well with the pharmacopoeia method.
Keywords: atropine; β-cyclodextrin; ion sensitive field effect transistor; drug analysis. atropine; β-cyclodextrin; ion sensitive field effect transistor; drug analysis.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Li, X.-W.; Yang, B.-L.; Wu, Y.-Y.; Lin, H.-Y. Determination of Atropine in Injection with β-Cyclodextrin Modified Ion Sensitive Field Effect Transistor Sensor. Sensors 2005, 5, 604-612.

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