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Integration of a Capacitive EIS Sensor into a FIA System for pH and Penicillin Determination
University of Applied Sciences, Aachen (Division Jülich), Laboratory for Chemical Sensors and Biosensors, Ginsterweg 1, D-52428, Jülich, Germany
Institute of Thin Films and Interfaces (ISG-2), Research Centre Jülich, D-52425 Jülich, Germany
* Author to whom correspondence should be addressed.
Received: 13 June 2004; Accepted: 17 August 2004 / Published: 30 August 2004
Abstract: A field-effect based capacitive EIS (electrolyte-insulator-semiconductor) sensor with a p-Si-SiO2-Ta2O5 structure has been successfully integrated into a commercial FIA (flow-injection analysis) system and system performances have been proven and optimised for pH and penicillin detection. A flow-through cell was designed taking into account the requirement of a variable internal volume (from 12 μl up to 48 μl) as well as an easy replacement of the EIS sensor. FIA parameters (sample volume, flow rate, distance between the injection valve and the EIS sensor) have been optimised in terms of high sensitivity and reproducibility as well as a minimum dispersion of the injected sample zone. An acceptable compromise between different FIA parameters has been found. For the cell design used in this study, best results have been achieved with a flow rate of 1.4 ml/min, distance between the injection valve and the EIS sensor of 6.5 cm, probe volume of 0.75 ml, cell internal volume of 12 μl. A sample throughput of at least 15 samples/h was typically obtained.
Keywords: FIA system; capacitive EIS sensor; flow-through cell; pH; penicillin
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MDPI and ACS Style
Rolka, D.; Poghossian, A.; Schöning, M.J. Integration of a Capacitive EIS Sensor into a FIA System for pH and Penicillin Determination. Sensors 2004, 4, 84-94.
Rolka D, Poghossian A, Schöning MJ. Integration of a Capacitive EIS Sensor into a FIA System for pH and Penicillin Determination. Sensors. 2004; 4(6):84-94.
Rolka, David; Poghossian, Arshak; Schöning, Michael J. 2004. "Integration of a Capacitive EIS Sensor into a FIA System for pH and Penicillin Determination." Sensors 4, no. 6: 84-94.