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Sensors 2017, 17(9), 2050; https://doi.org/10.3390/s17092050

Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery

1
School of Mechanical and Aerospace Engineering & ReCAPT, Gyeongsang National University, Jinju 660-701, Korea
2
School of Naval Architecture and Ocean Engineering, Harbin Institute of Technology at Weihai, Weihai 264209, China
3
Faculty of Industrial and Mechanical Engineering, Islamic Azad University, Qazvin Branch, Qazvin 34199-15195, Iran
4
School of Integrated Technology, Gwangju Institute of Science and Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju 61005, Korea
*
Author to whom correspondence should be addressed.
Received: 1 August 2017 / Revised: 28 August 2017 / Accepted: 1 September 2017 / Published: 7 September 2017
(This article belongs to the Special Issue Magnetic Sensors and Their Applications)
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Abstract

Magnetic nanoparticles (MNPs) are effective drug carriers. By using electromagnetic actuated systems, MNPs can be controlled noninvasively in a vascular network for targeted drug delivery (TDD). Although drugs can reach their target location through capturing schemes of MNPs by permanent magnets, drugs delivered to non-target regions can affect healthy tissues and cause undesirable side effects. Real-time monitoring of MNPs can improve the targeting efficiency of TDD systems. In this paper, a two-dimensional (2D) real-time monitoring scheme has been developed for an MNP guidance system. Resovist particles 45 to 65 nm in diameter (5 nm core) can be monitored in real-time (update rate = 2 Hz) in 2D. The proposed 2D monitoring system allows dynamic tracking of MNPs during TDD and renders magnetic particle imaging-based navigation more feasible. View Full-Text
Keywords: magnetic particle imaging; navigation resolution; magnetic nanoparticles magnetic particle imaging; navigation resolution; magnetic nanoparticles
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Le, T.-A.; Zhang, X.; Hoshiar, A.K.; Yoon, J. Real-Time Two-Dimensional Magnetic Particle Imaging for Electromagnetic Navigation in Targeted Drug Delivery. Sensors 2017, 17, 2050.

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