A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform
AbstractWe present a complete biosensing system that comprises a Thin Film Transistor (TFT)-based nanoribbon biosensor and a low noise, high-performance bioinstrumentation platform, capable of detecting sub-30 mpH unit changes, validated by an enzymatic biochemical reaction. The nanoribbon biosensor was fabricated top-down with an ultra-thin (15 nm) polysilicon semiconducting channel that offers excellent sensitivity to surface potential changes. The sensor is coupled to an integrated circuit (IC), which combines dual switched-capacitor integrators with high precision analog-to-digital converters (ADCs). Throughout this work, we employed both conventional pH buffer measurements as well as urea-urease enzymatic reactions for benchmarking the overall performance of the system. The measured results from the urea-urease reaction demonstrate that the system can detect urea in concentrations as low as 25 μM, which translates to a change of 27 mpH, according to our initial pH characterisation measurements. The attained accuracy and resolution of our system as well as its low-cost manufacturability, high processing speed and portability make it a competitive solution for applications requiring rapid and accurate results at remote locations; a necessity for Point-of-Care (POC) diagnostic platforms. View Full-Text
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Zeimpekis, I.; Papadimitriou, K.I.; Sun, K.; Hu, C.; Ashburn, P.; Morgan, H.; Prodromakis, T. A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform. Sensors 2017, 17, 2000.
Zeimpekis I, Papadimitriou KI, Sun K, Hu C, Ashburn P, Morgan H, Prodromakis T. A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform. Sensors. 2017; 17(9):2000.Chicago/Turabian Style
Zeimpekis, Ioannis; Papadimitriou, Konstantinos I.; Sun, Kai; Hu, Chunxiao; Ashburn, Peter; Morgan, Hywel; Prodromakis, Themistoklis. 2017. "A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform." Sensors 17, no. 9: 2000.
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