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Sensors 2017, 17(9), 2000; doi:10.3390/s17092000

A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform

Nanoelectronics & Nanotechnology Research Group, Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK
These authors contributed equally to this work.
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Received: 3 July 2017 / Revised: 23 August 2017 / Accepted: 28 August 2017 / Published: 1 September 2017
(This article belongs to the Special Issue Thin-Film Transistors for Biomedical and Chemical Sensing)
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Abstract

We present a complete biosensing system that comprises a Thin Film Transistor (TFT)-based nanoribbon biosensor and a low noise, high-performance bioinstrumentation platform, capable of detecting sub-30 mpH unit changes, validated by an enzymatic biochemical reaction. The nanoribbon biosensor was fabricated top-down with an ultra-thin (15 nm) polysilicon semiconducting channel that offers excellent sensitivity to surface potential changes. The sensor is coupled to an integrated circuit (IC), which combines dual switched-capacitor integrators with high precision analog-to-digital converters (ADCs). Throughout this work, we employed both conventional pH buffer measurements as well as urea-urease enzymatic reactions for benchmarking the overall performance of the system. The measured results from the urea-urease reaction demonstrate that the system can detect urea in concentrations as low as 25 μM, which translates to a change of 27 mpH, according to our initial pH characterisation measurements. The attained accuracy and resolution of our system as well as its low-cost manufacturability, high processing speed and portability make it a competitive solution for applications requiring rapid and accurate results at remote locations; a necessity for Point-of-Care (POC) diagnostic platforms. View Full-Text
Keywords: analog-to-digital conversion; biosensor; nanoribbon; pH sensing; Point-of-Care diagnostics; switched capacitor; TFT; urea-urease reaction analog-to-digital conversion; biosensor; nanoribbon; pH sensing; Point-of-Care diagnostics; switched capacitor; TFT; urea-urease reaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zeimpekis, I.; Papadimitriou, K.I.; Sun, K.; Hu, C.; Ashburn, P.; Morgan, H.; Prodromakis, T. A Sub-30 mpH Resolution Thin Film Transistor-Based Nanoribbon Biosensing Platform. Sensors 2017, 17, 2000.

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