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Sensors 2017, 17(8), 1795; doi:10.3390/s17081795

Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays

1
Department of Metallurgical Engineering, University of Utah, Salt Lake City, UT 84112, USA
2
Department of Chemical Engineering, University of Utah, Salt Lake City, UT 84112, USA
*
Author to whom correspondence should be addressed.
Received: 27 June 2017 / Revised: 31 July 2017 / Accepted: 1 August 2017 / Published: 4 August 2017
(This article belongs to the Special Issue Biosensors for Cancer Biomarkers)
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Abstract

Screening of colorectal cancer is crucial for early stage diagnosis and treatment. Detection of volatile organic compounds (VOCs) of the metabolome present in exhaled breath is a promising approach to screen colorectal cancer (CRC). Various forms of volatile organic compounds (VOCs) that show the definitive signature for the different diseases including cancers are present in exhale breathe. Among all the reported CRC VOCs, cyclohexane, methylcyclohexane, 1,3-dimethyl- benzene and decanal are identified as the prominent ones that can be used as the signature for CRC screening. In the present investigation, detection of the four prominent VOCs related to CRC is explored using functionalized titania nanotubular arrays (TNAs)-based sensor. These signature biomarkers are shown to be detected using nickel-functionalized TNA as an electrochemical sensor. The sensing mechanism is based on the electrochemical interaction of nickel-functionalized nanotubes with signature biomarkers. A detailed mechanism of the sensor response is also presented. View Full-Text
Keywords: sensor; colorectal cancer; volatile organic biomarkers; titania nanotubes; cancer biomarkers sensor; colorectal cancer; volatile organic biomarkers; titania nanotubes; cancer biomarkers
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Bhattacharyya, D.; Kumar, P.; Mohanty, S.K.; Smith, Y.R.; Misra, M. Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays. Sensors 2017, 17, 1795.

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