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Sensors 2017, 17(8), 1736; https://doi.org/10.3390/s17081736

Aptamer-Modified Semiconductor Quantum Dots for Biosensing Applications

1
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Aptamer Engineering Center of Hunan Province, Changsha 410082, China
2
College of Life Sciences, Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, Hunan University, Aptamer Engineering Center of Hunan Province, Changsha 410082, China
*
Authors to whom correspondence should be addressed.
Received: 11 May 2017 / Revised: 21 June 2017 / Accepted: 7 July 2017 / Published: 28 July 2017
(This article belongs to the Special Issue Semiconductor Materials on Biosensors Application)
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Abstract

Semiconductor quantum dots have attracted extensive interest in the biosensing area because of their properties, such as narrow and symmetric emission with tunable colors, high quantum yield, high stability and controllable morphology. The introduction of various reactive functional groups on the surface of semiconductor quantum dots allows one to conjugate a spectrum of ligands, antibodies, peptides, or nucleic acids for broader and smarter applications. Among these ligands, aptamers exhibit many advantages including small size, high chemical stability, simple synthesis with high batch-to-batch consistency and convenient modification. More importantly, it is easy to introduce nucleic acid amplification strategies and/or nanomaterials to improve the sensitivity of aptamer-based sensing systems. Therefore, the combination of semiconductor quantum dots and aptamers brings more opportunities in bioanalysis. Here we summarize recent advances on aptamer-functionalized semiconductor quantum dots in biosensing applications. Firstly, we discuss the properties and structure of semiconductor quantum dots and aptamers. Then, the applications of biosensors based on aptamer-modified semiconductor quantum dots by different signal transducing mechanisms, including optical, electrochemical and electrogenerated chemiluminescence approaches, is discussed. Finally, our perspectives on the challenges and opportunities in this promising field are provided. View Full-Text
Keywords: semiconductor quantum dots; aptamer; biosensors semiconductor quantum dots; aptamer; biosensors
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Wen, L.; Qiu, L.; Wu, Y.; Hu, X.; Zhang, X. Aptamer-Modified Semiconductor Quantum Dots for Biosensing Applications. Sensors 2017, 17, 1736.

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