Next Article in Journal
Enhanced Handover Decision Algorithm in Heterogeneous Wireless Network
Next Article in Special Issue
Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays
Previous Article in Journal
A Wi-Fi Union Mechanism for Internet Advertising Reciprocal Platform in Microenterprises
Previous Article in Special Issue
Early Diagnosis of Breast Cancer
Article Menu
Issue 7 (July) cover image

Export Article

Erratum published on 30 October 2017, see Sensors 2017, 17(11), 2492.

Open AccessArticle
Sensors 2017, 17(7), 1580; https://doi.org/10.3390/s17071580

Novel Selective Detection Method of Tumor Angiogenesis Factors Using Living Nano-Robots

1
Nanotechnology Institute, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
2
Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
3
Micro and Nano Systems Lab., Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan
*
Author to whom correspondence should be addressed.
Received: 8 May 2017 / Revised: 24 June 2017 / Accepted: 1 July 2017 / Published: 14 July 2017
(This article belongs to the Special Issue Biosensors for Cancer Biomarkers)
View Full-Text   |   Download PDF [2560 KB, uploaded 1 November 2017]   |  

Abstract

This paper reports a novel self-detection method for tumor cells using living nano-robots. These living robots are a nonpathogenic strain of E. coli bacteria equipped with naturally synthesized bio-nano-sensory systems that have an affinity to VEGF, an angiogenic factor overly-expressed by cancer cells. The VEGF-affinity/chemotaxis was assessed using several assays including the capillary chemotaxis assay, chemotaxis assay on soft agar, and chemotaxis assay on solid agar. In addition, a microfluidic device was developed to possibly discover tumor cells through the overexpressed vascular endothelial growth factor (VEGF). Various experiments to study the sensing characteristic of the nano-robots presented a strong response toward the VEGF. Thus, a new paradigm of selective targeting therapies for cancer can be advanced using swimming E. coli as self-navigator miniaturized robots as well as drug-delivery vehicles. View Full-Text
Keywords: bio-nanosensor; bacteria; nano-robot; chemotaxis; cancer therapy; microfluidics bio-nanosensor; bacteria; nano-robot; chemotaxis; cancer therapy; microfluidics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Al-Fandi, M.; Alshraiedeh, N.; Oweis, R.; Alshdaifat, H.; Al-Mahaseneh, O.; Al-Tall, K.; Alawneh, R. Novel Selective Detection Method of Tumor Angiogenesis Factors Using Living Nano-Robots. Sensors 2017, 17, 1580.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top