Novel Selective Detection Method of Tumor Angiogenesis Factors Using Living Nano-Robots
AbstractThis paper reports a novel self-detection method for tumor cells using living nano-robots. These living robots are a nonpathogenic strain of E. coli bacteria equipped with naturally synthesized bio-nano-sensory systems that have an affinity to VEGF, an angiogenic factor overly-expressed by cancer cells. The VEGF-affinity/chemotaxis was assessed using several assays including the capillary chemotaxis assay, chemotaxis assay on soft agar, and chemotaxis assay on solid agar. In addition, a microfluidic device was developed to possibly discover tumor cells through the overexpressed vascular endothelial growth factor (VEGF). Various experiments to study the sensing characteristic of the nano-robots presented a strong response toward the VEGF. Thus, a new paradigm of selective targeting therapies for cancer can be advanced using swimming E. coli as self-navigator miniaturized robots as well as drug-delivery vehicles. View Full-Text
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Al-Fandi, M.; Alshraiedeh, N.; Oweis, R.; Alshdaifat, H.; Al-Mahaseneh, O.; Al-Tall, K.; Alawneh, R. Novel Selective Detection Method of Tumor Angiogenesis Factors Using Living Nano-Robots. Sensors 2017, 17, 1580.
Al-Fandi M, Alshraiedeh N, Oweis R, Alshdaifat H, Al-Mahaseneh O, Al-Tall K, Alawneh R. Novel Selective Detection Method of Tumor Angiogenesis Factors Using Living Nano-Robots. Sensors. 2017; 17(7):1580.Chicago/Turabian Style
Al-Fandi, Mohamed; Alshraiedeh, Nida; Oweis, Rami; Alshdaifat, Hala; Al-Mahaseneh, Omamah; Al-Tall, Khadijah; Alawneh, Rawan. 2017. "Novel Selective Detection Method of Tumor Angiogenesis Factors Using Living Nano-Robots." Sensors 17, no. 7: 1580.
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