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Sensors 2017, 17(6), 1306; doi:10.3390/s17061306

Bioluminescence Assays for Monitoring Chondrogenic Differentiation and Cartilage Regeneration

Department of Physical Therapy and Rehabilitation Science, College of Health Science, Eulji University, Gyeonggi 13135, Korea
Author to whom correspondence should be addressed.
Academic Editor: Yong Liu
Received: 8 May 2017 / Revised: 24 May 2017 / Accepted: 2 June 2017 / Published: 6 June 2017
(This article belongs to the Special Issue Whole Cell-Based Biosensors and Application)
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Since articular cartilage has a limited regeneration potential, for developing biological therapies for cartilage regeneration it is important to study the mechanisms underlying chondrogenesis of stem cells. Bioluminescence assays can visualize a wide range of biological phenomena such as gene expression, signaling, metabolism, development, cellular movements, and molecular interactions by using visible light and thus contribute substantially to elucidation of their biological functions. This article gives a concise review to introduce basic principles of bioluminescence assays and applications of the technology to visualize the processes of chondrogenesis and cartilage regeneration. Applications of bioluminescence assays have been highlighted in the methods of real-time monitoring of gene expression and intracellular levels of biomolecules and noninvasive cell tracking within animal models. This review suggests that bioluminescence assays can be applied towards a visual understanding of chondrogenesis and cartilage regeneration. View Full-Text
Keywords: bioluminescence assays; cartilage regeneration; chondrogenesis; real-time monitoring; in vivo bioluminescence imaging bioluminescence assays; cartilage regeneration; chondrogenesis; real-time monitoring; in vivo bioluminescence imaging

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Je, H.J.; Kim, M.G.; Kwon, H.J. Bioluminescence Assays for Monitoring Chondrogenic Differentiation and Cartilage Regeneration. Sensors 2017, 17, 1306.

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