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Sensors 2017, 17(6), 1293; doi:10.3390/s17061293

Cell Microarray Technologies for High-Throughput Cell-Based Biosensors

1
Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea
2
Department of Radiation Oncology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Yong Liu
Received: 30 March 2017 / Revised: 24 May 2017 / Accepted: 31 May 2017 / Published: 5 June 2017
(This article belongs to the Special Issue Whole Cell-Based Biosensors and Application)

Abstract

Due to the recent demand for high-throughput cellular assays, a lot of efforts have been made on miniaturization of cell-based biosensors by preparing cell microarrays. Various microfabrication technologies have been used to generate cell microarrays, where cells of different phenotypes are immobilized either on a flat substrate (positional array) or on particles (solution or suspension array) to achieve multiplexed and high-throughput cell-based biosensing. After introducing the fabrication methods for preparation of the positional and suspension cell microarrays, this review discusses the applications of the cell microarray including toxicology, drug discovery and detection of toxic agents. View Full-Text
Keywords: cell-based biosensor; cell microarray; microfabrication; toxicology; drug discovery; biosensing; positional array; suspension array cell-based biosensor; cell microarray; microfabrication; toxicology; drug discovery; biosensing; positional array; suspension array
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hong, H.J.; Koom, W.S.; Koh, W.-G. Cell Microarray Technologies for High-Throughput Cell-Based Biosensors. Sensors 2017, 17, 1293.

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