Next Article in Journal
Distributed and Modular CAN-Based Architecture for Hardware Control and Sensor Data Integration
Next Article in Special Issue
Noise Attenuation Performance of a Helmholtz Resonator Array Consist of Several Periodic Parts
Previous Article in Journal
A Study of the CO Sensing Responses of Cu-, Pt- and Pd-Activated SnO2 Sensors: Effect of Precipitation Agents, Dopants and Doping Methods
Previous Article in Special Issue
SAW Sensors for Chemical Vapors and Gases
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Sensors 2017, 17(5), 1015; doi:10.3390/s17051015

ZnO Film Bulk Acoustic Resonator for the Kinetics Study of Human Blood Coagulation

State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, College of Electronics, Communications, and Physics, Shandong University of Science and Technology, Qingdao 266590, China
*
Author to whom correspondence should be addressed.
Academic Editors: Jikui Luo, Weipeng Xuan and Richard Yong Qing Fu
Received: 27 March 2017 / Revised: 20 April 2017 / Accepted: 25 April 2017 / Published: 3 May 2017
(This article belongs to the Special Issue Acoustic Wave Resonator-Based Sensors)
View Full-Text   |   Download PDF [3728 KB, uploaded 12 May 2017]   |  

Abstract

Miniaturized and rapid blood coagulation assay technologies are critical in many clinical settings. In this paper, we present a ZnO film bulk acoustic resonator for the kinetic analysis of human blood coagulation. The resonator operated in thickness shear resonance mode at 1.4 GHz. When the resonator contacted the liquid environment, the viscous loading effect was considered as the additional resistance and inductance in the equivalent circuits, resulting in a linear relationship with a slope of approximately −217 kHz/cP between the liquid viscosity and the frequency of the resonator. The downshift of the resonant frequency and the viscosity change during the blood coagulation were correlated to monitor the coagulation process. The sigmoidal trend was observed in the frequency response for the blood samples activated by thromboplastin and calcium ions. The coagulation kinetics involving sequential phases of steady reaction, growth and saturation were revealed through the time-dependent frequency profiles. The enzymatic cascade time, the coagulation rate, the coagulation time and the clot degree were provided by fitting the time-frequency curves. The prothrombin times were compared with the results measured by a standard coagulometer and show a good correlation. Thanks to the excellent potential of integration, miniaturization and the availability of direct digital signals, the film bulk acoustic resonator has promising application for both clinical and personal use coagulation testing technologies. View Full-Text
Keywords: ZnO film; film bulk acoustic resonator; viscosity sensor; coagulation monitoring ZnO film; film bulk acoustic resonator; viscosity sensor; coagulation monitoring
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chen, D.; Zhang, Z.; Ma, J.; Wang, W. ZnO Film Bulk Acoustic Resonator for the Kinetics Study of Human Blood Coagulation. Sensors 2017, 17, 1015.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top