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Sensors 2017, 17(4), 898; doi:10.3390/s17040898

Molecular Imprinting of Macromolecules for Sensor Applications

1
Department of Chemistry, Division of Biochemistry, Hacettepe University, 06800 Ankara, Turkey
2
Department of Chemistry Technology, Abant Izzet Baysal University, 14900 Bolu, Turkey
*
Author to whom correspondence should be addressed.
Academic Editors: Gizem Ertürk and Bo Mattiasson
Received: 31 January 2017 / Revised: 7 April 2017 / Accepted: 7 April 2017 / Published: 19 April 2017
(This article belongs to the Special Issue Biosensors and Molecular Imprinting)

Abstract

Molecular recognition has an important role in numerous living systems. One of the most important molecular recognition methods is molecular imprinting, which allows host compounds to recognize and detect several molecules rapidly, sensitively and selectively. Compared to natural systems, molecular imprinting methods have some important features such as low cost, robustness, high recognition ability and long term durability which allows molecularly imprinted polymers to be used in various biotechnological applications, such as chromatography, drug delivery, nanotechnology, and sensor technology. Sensors are important tools because of their ability to figure out a potentially large number of analytical difficulties in various areas with different macromolecular targets. Proteins, enzymes, nucleic acids, antibodies, viruses and cells are defined as macromolecules that have wide range of functions are very important. Thus, macromolecules detection has gained great attention in concerning the improvement in most of the studies. The applications of macromolecule imprinted sensors will have a spacious exploration according to the low cost, high specificity and stability. In this review, macromolecules for molecularly imprinted sensor applications are structured according to the definition of molecular imprinting methods, developments in macromolecular imprinting methods, macromolecular imprinted sensors, and conclusions and future perspectives. This chapter follows the latter strategies and focuses on the applications of macromolecular imprinted sensors. This allows discussion on how sensor strategy is brought to solve the macromolecules imprinting. View Full-Text
Keywords: macromolecule; molecular imprinting; sensor macromolecule; molecular imprinting; sensor
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MDPI and ACS Style

Saylan, Y.; Yilmaz, F.; Özgür, E.; Derazshamshir, A.; Yavuz, H.; Denizli, A. Molecular Imprinting of Macromolecules for Sensor Applications. Sensors 2017, 17, 898.

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