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Sensors 2017, 17(3), 454; doi:10.3390/s17030454

Molecular Imprinting Technology in Quartz Crystal Microbalance (QCM) Sensors

1
Chemistry Department, Faculty of Science, Anadolu University, 26470 Eskisehir, Turkey
2
Department of Medical Services and Techniques, Yunus Emre Vocational School of Health Services, Anadolu University, 26470 Eskisehir, Turkey
3
Bionkit Co. Ltd., 26470 Eskisehir, Turkey
*
Author to whom correspondence should be addressed.
Academic Editors: Bo Mattiasson and Gizem Ertürk
Received: 15 December 2016 / Revised: 20 February 2017 / Accepted: 21 February 2017 / Published: 24 February 2017
(This article belongs to the Special Issue Biosensors and Molecular Imprinting)
View Full-Text   |   Download PDF [2267 KB, uploaded 24 February 2017]   |  

Abstract

Molecularly imprinted polymers (MIPs) as artificial antibodies have received considerable scientific attention in the past years in the field of (bio)sensors since they have unique features that distinguish them from natural antibodies such as robustness, multiple binding sites, low cost, facile preparation and high stability under extreme operation conditions (higher pH and temperature values, etc.). On the other hand, the Quartz Crystal Microbalance (QCM) is an analytical tool based on the measurement of small mass changes on the sensor surface. QCM sensors are practical and convenient monitoring tools because of their specificity, sensitivity, high accuracy, stability and reproducibility. QCM devices are highly suitable for converting the recognition process achieved using MIP-based memories into a sensor signal. Therefore, the combination of a QCM and MIPs as synthetic receptors enhances the sensitivity through MIP process-based multiplexed binding sites using size, 3D-shape and chemical function having molecular memories of the prepared sensor system toward the target compound to be detected. This review aims to highlight and summarize the recent progress and studies in the field of (bio)sensor systems based on QCMs combined with molecular imprinting technology. View Full-Text
Keywords: molecularly imprinted polymers (MIPs); quartz crystal microbalance (QCM); biosensors; biomolecular recognition; synthetic receptors molecularly imprinted polymers (MIPs); quartz crystal microbalance (QCM); biosensors; biomolecular recognition; synthetic receptors
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Emir Diltemiz, S.; Keçili, R.; Ersöz, A.; Say, R. Molecular Imprinting Technology in Quartz Crystal Microbalance (QCM) Sensors. Sensors 2017, 17, 454.

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