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Sensors 2017, 17(2), 256; doi:10.3390/s17020256

Analytical Protein Microarrays: Advancements Towards Clinical Applications

AIT Austrian Institute of Technology GmbH, Center for Health and Bioresources, 3430 Tulln, Austria
Academic Editors: Eiichi Tamiya, Yuji Murakami Tatsuro Endo and Mundelanji Vestergaard
Received: 28 November 2016 / Revised: 13 January 2017 / Accepted: 23 January 2017 / Published: 29 January 2017
(This article belongs to the Special Issue Point-of-Care Biosensors)
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Abstract

Protein microarrays represent a powerful technology with the potential to serve as tools for the detection of a broad range of analytes in numerous applications such as diagnostics, drug development, food safety, and environmental monitoring. Key features of analytical protein microarrays include high throughput and relatively low costs due to minimal reagent consumption, multiplexing, fast kinetics and hence measurements, and the possibility of functional integration. So far, especially fundamental studies in molecular and cell biology have been conducted using protein microarrays, while the potential for clinical, notably point-of-care applications is not yet fully utilized. The question arises what features have to be implemented and what improvements have to be made in order to fully exploit the technology. In the past we have identified various obstacles that have to be overcome in order to promote protein microarray technology in the diagnostic field. Issues that need significant improvement to make the technology more attractive for the diagnostic market are for instance: too low sensitivity and deficiency in reproducibility, inadequate analysis time, lack of high-quality antibodies and validated reagents, lack of automation and portable instruments, and cost of instruments necessary for chip production and read-out. The scope of the paper at hand is to review approaches to solve these problems. View Full-Text
Keywords: point-of-care; arrayed biosensors; miniaturization; optical signal transduction; protein biomarker point-of-care; arrayed biosensors; miniaturization; optical signal transduction; protein biomarker
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Sauer, U. Analytical Protein Microarrays: Advancements Towards Clinical Applications. Sensors 2017, 17, 256.

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