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Sensors 2017, 17(12), 2760; doi:10.3390/s17122760

Highly Sensitive FPW-Based Microsystem for Rapid Detection of Tetrahydrocannabinol in Human Urine

1
Department of Electrical Engineering, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
2
Department of Engineering Science, National Cheng Kung University, Tainan 70101, Taiwan
*
Author to whom correspondence should be addressed.
Received: 13 October 2017 / Revised: 21 November 2017 / Accepted: 23 November 2017 / Published: 29 November 2017
(This article belongs to the Special Issue Bio-MEMS for Precision Medicine)
View Full-Text   |   Download PDF [3928 KB, uploaded 29 November 2017]   |  

Abstract

This paper presents a highly sensitive flexural plate-wave (FPW)-based microsystem for rapid detection of tetrahydrocannabinol (THC) in human urine. First, a circular-type interdigital transducer (IDT) was integrated with a circular-type silicon-grooved reflective grating structure (RGS) to reduce insertion loss. Then, with lower insertion loss (−38.758 dB), the FPW device was used to develop a novel THC biosensor, and the results reveal that this FPW-THC biosensor has low detection limit (1.5625 ng/mL) and high mass-sensitivity (126.67 cm2/g). Finally, this biosensor was integrated with field-programmable gate array (FPGA) board and discrete components for prototyping a FPW readout system, whose maximum error was 12.378 kHz to ensure that the linearity of detection up to R-square is equal to 0.9992. View Full-Text
Keywords: flexural plate-wave; tetrahydrocannabinol; circular-type interdigital transducer; reflective grating structure; low insertion loss; field-programmable gate array; readout system flexural plate-wave; tetrahydrocannabinol; circular-type interdigital transducer; reflective grating structure; low insertion loss; field-programmable gate array; readout system
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lan, J.-W.; Hsieh, C.-H.; Huang, I.-Y.; Lin, Y.-C.; Tsai, T.-Y.; Wang, C.-C. Highly Sensitive FPW-Based Microsystem for Rapid Detection of Tetrahydrocannabinol in Human Urine. Sensors 2017, 17, 2760.

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