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Sensors 2017, 17(11), 2689; https://doi.org/10.3390/s17112689

Selectivity/Specificity Improvement Strategies in Surface-Enhanced Raman Spectroscopy Analysis

The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, China
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Received: 28 September 2017 / Revised: 31 October 2017 / Accepted: 12 November 2017 / Published: 21 November 2017
(This article belongs to the Special Issue Surface Plasmon Resonance Sensing)
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Abstract

Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for the discrimination, identification, and potential quantification of certain compounds/organisms. However, its real application is challenging due to the multiple interference from the complicated detection matrix. Therefore, selective/specific detection is crucial for the real application of SERS technique. We summarize in this review five selective/specific detection techniques (chemical reaction, antibody, aptamer, molecularly imprinted polymers and microfluidics), which can be applied for the rapid and reliable selective/specific detection when coupled with SERS technique. View Full-Text
Keywords: surface-enhanced Raman spectroscopy; specificity; selectivity; chemical reaction; antibody; aptamer; molecularly imprinted polymers; microfluidics surface-enhanced Raman spectroscopy; specificity; selectivity; chemical reaction; antibody; aptamer; molecularly imprinted polymers; microfluidics
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Wang, F.; Cao, S.; Yan, R.; Wang, Z.; Wang, D.; Yang, H. Selectivity/Specificity Improvement Strategies in Surface-Enhanced Raman Spectroscopy Analysis. Sensors 2017, 17, 2689.

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