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Sensors 2016, 16(8), 1197; doi:10.3390/s16081197

Integrating a DNA Strand Displacement Reaction with a Whispering Gallery Mode Sensor for Label-Free Mercury (II) Ion Detection

1
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
2
University of Chinese Academy of Sciences, Beijing 100080, China
3
Laboratory of Nanophotonics & Biosensing, Max Planck Institute for the Science of Light, Erlangen D-91058, Germany
4
Division of Biomedical Engineering, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Alexandre Francois, Al Meldrum and Nicolas Riesen
Received: 18 June 2016 / Revised: 20 July 2016 / Accepted: 25 July 2016 / Published: 29 July 2016
(This article belongs to the Special Issue Label-Free Optical Biosensors)
View Full-Text   |   Download PDF [1838 KB, uploaded 29 July 2016]   |  

Abstract

Mercury is an extremely toxic chemical pollutant of our environment. It has attracted the world’s attention due to its high mobility and the ease with which it accumulates in organisms. Sensitive devices and methods specific for detecting mercury ions are, hence, in great need. Here, we have integrated a DNA strand displacement reaction with a whispering gallery mode (WGM) sensor for demonstrating the detection of Hg2+ ions. Our approach relies on the displacement of a DNA hairpin structure, which forms after the binding of mercury ions to an aptamer DNA sequence. The strand displacement reaction of the DNA aptamer provides highly specific and quantitative means for determining the mercury ion concentration on a label-free WGM sensor platform. Our approach also shows the possibility for manipulating the kinetics of a strand displacement reaction with specific ionic species. View Full-Text
Keywords: whispering gallery mode; DNA strand displacement; Mercury (II) ions detection; biosensing; label-free detection; optical microcavity; DNA nanotechnology whispering gallery mode; DNA strand displacement; Mercury (II) ions detection; biosensing; label-free detection; optical microcavity; DNA nanotechnology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Wu, F.; Wu, Y.; Niu, Z.; Vollmer, F. Integrating a DNA Strand Displacement Reaction with a Whispering Gallery Mode Sensor for Label-Free Mercury (II) Ion Detection. Sensors 2016, 16, 1197.

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