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Sensors 2016, 16(6), 915; doi:10.3390/s16060915

Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring

1
IMS, University Bordeaux, CNRS UMR 5218, Bordeaux INP, 33405 Talence, France
2
LAAS, CNRS UPR 8001, 31031 Toulouse, France
3
Normandie Univ., UNICAEN, UNIROUEN, ABTE, 14000 Caen, France
4
Comprehensive Cancer Center François Baclesse, UNICANCER, 14076 Caen, France
5
ICOA, University Orléans, CNRS, CNRS UMR 7311, F-45067 Orléans, France
*
Author to whom correspondence should be addressed.
Academic Editor: Carmen Horrillo Güemes
Received: 9 April 2016 / Revised: 9 June 2016 / Accepted: 14 June 2016 / Published: 20 June 2016
(This article belongs to the Special Issue E-noses: Sensors and Applications)
View Full-Text   |   Download PDF [3102 KB, uploaded 22 June 2016]   |  

Abstract

Cancer is a leading cause of death worldwide and actual analytical techniques are restrictive in detecting it. Thus, there is still a challenge, as well as a need, for the development of quantitative non-invasive tools for the diagnosis of cancers and the follow-up care of patients. We introduce first the overall interest of electronic nose or tongue for such application of microsensors arrays with data processing in complex media, either gas (e.g., Volatile Organic Compounds or VOCs as biomarkers in breath) or liquid (e.g., modified nucleosides as urinary biomarkers). Then this is illustrated with a versatile acoustic wave transducer, functionalized with molecularly-imprinted polymers (MIP) synthesized for adenosine-5′-monophosphate (AMP) as a model for nucleosides. The device including the thin film coating is described, then static measurements with scanning electron microscopy (SEM) and electrical characterization after each step of the sensitive MIP process (deposit, removal of AMP template, capture of AMP target) demonstrate the thin film functionality. Dynamic measurements with a microfluidic setup and four targets are presented afterwards. They show a sensitivity of 5 Hz·ppm−1 of the non-optimized microsensor for AMP detection, with a specificity of three times compared to PMPA, and almost nil sensitivity to 3′AMP and CMP, in accordance with previously published results on bulk MIP. View Full-Text
Keywords: chemical sensor; surface acoustic wave; MIP; nucleoside; cancer biomarker; urinary; microfluidic; electronic tongue chemical sensor; surface acoustic wave; MIP; nucleoside; cancer biomarker; urinary; microfluidic; electronic tongue
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dejous, C.; Hallil, H.; Raimbault, V.; Lachaud, J.-L.; Plano, B.; Delépée, R.; Favetta, P.; Agrofoglio, L.; Rebière, D. Love Acoustic Wave-Based Devices and Molecularly-Imprinted Polymers as Versatile Sensors for Electronic Nose or Tongue for Cancer Monitoring. Sensors 2016, 16, 915.

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