Next Article in Journal
Feature Selection Method Based on Neighborhood Relationships: Applications in EEG Signal Identification and Chinese Character Recognition
Next Article in Special Issue
Biosensing by WGM Microspherical Resonators
Previous Article in Journal
A Novel Azimuth Super-Resolution Method by Synthesizing Azimuth Bandwidth of Multiple Tracks of Airborne Stripmap SAR Data
Previous Article in Special Issue
Molecular Spectrum Capture by Tuning the Chemical Potential of Graphene
Article Menu

Export Article

Open AccessReview
Sensors 2016, 16(6), 870; doi:10.3390/s16060870

SPR and SPR Imaging: Recent Trends in Developing Nanodevices for Detection and Real-Time Monitoring of Biomolecular Events

1
R&D Center LaborQ, University of Bucharest, 4-12 Regina Elisabeta Blvd., Bucharest 030018, Romania
2
Department of Analytical Chemistry, University of Bucharest, 4-12 Regina Elisabeta Blvd., Bucharest 030018, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Galina Nemova
Received: 26 April 2016 / Revised: 22 May 2016 / Accepted: 1 June 2016 / Published: 14 June 2016
(This article belongs to the Special Issue SPR, WGM & Nano-Sensors: Advantages and Prospects)
View Full-Text   |   Download PDF [2591 KB, uploaded 14 June 2016]   |  

Abstract

In this paper we review the underlying principles of the surface plasmon resonance (SPR) technique, particularly emphasizing its advantages along with its limitations regarding the ability to discriminate between the specific binding response and the interfering effects from biological samples. While SPR sensors were developed almost three decades, SPR detection is not yet able to reduce the time-consuming steps of the analysis, and is hardly amenable for miniaturized, portable platforms required in point-of-care (POC) testing. Recent advances in near-field optics have emerged, resulting in the development of SPR imaging (SPRi) as a powerful optical, label-free monitoring tool for multiplexed detection and monitoring of biomolecular events. The microarrays design of the SPRi chips incorporating various metallic nanostructures make these optofluidic devices more suitable for diagnosis and near-patient testing than the traditional SPR sensors. The latest developments indicate SPRi detection as being the most promising surface plasmon-based technique fulfilling the demands for implementation in lab-on-a-chip (LOC) technologies. View Full-Text
Keywords: surface plasmon resonance imaging; microfluidics; lab-on-a-chip; point-of-care-testing surface plasmon resonance imaging; microfluidics; lab-on-a-chip; point-of-care-testing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Puiu, M.; Bala, C. SPR and SPR Imaging: Recent Trends in Developing Nanodevices for Detection and Real-Time Monitoring of Biomolecular Events. Sensors 2016, 16, 870.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top