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Sensors 2016, 16(5), 694; doi:10.3390/s16050694

Current Developments on Optical Feedback Interferometry as an All-Optical Sensor for Biomedical Applications

1
LAAS-CNRS, Université de Toulouse, CNRS, INP, 6 AllÃée Emile Monso, 31400 Toulouse, France
2
Centre for the Development of Sensors, Instruments and Systems, Universitat Politècnica de Catalunya (UPC-CD6), Rambla Sant Nebridi 10, E08222 Terrassa, Spain
3
Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, Calle 30, No. 502, Miramar, La Habana 11300, Cuba
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Vittorio M. N. Passaro
Received: 1 March 2016 / Revised: 5 May 2016 / Accepted: 6 May 2016 / Published: 13 May 2016
(This article belongs to the Special Issue Infrared and THz Sensing and Imaging)

Abstract

Optical feedback interferometry (OFI) sensors are experiencing a consistent increase in their applications to biosensing due to their contactless nature, low cost and compactness, features that fit very well with current biophotonics research and market trends. The present paper is a review of the work in progress at UPC-CD6 and LAAS-CNRS related to the application of OFI to different aspects of biosensing, both in vivo and ex vivo. This work is intended to present the variety of opportunities and potential applications related to OFI that are available in the field. The activities presented are divided into two main sensing strategies: The measurement of optical path changes and the monitoring of flows, which correspond to sensing strategies linked to the reconstruction of changes of amplitude from the interferometric signal, and to classical Doppler frequency measurements, respectively. For optical path change measurements, measurements of transient pulses, usual in biosensing, together with the measurement of large displacements applied to designing palliative care instrumentation for Parkinson disease are discussed. Regarding the Doppler-based approach, progress in flow-related signal processing and applications in real-time monitoring of non-steady flows, human blood flow monitoring and OFI pressure myograph sensing will be presented. In all cases, experimental setups are discussed and results presented, showing the versatility of the technique. The described applications show the wide capabilities in biosensing of the OFI sensor, showing it as an enabler of low-cost, all-optical, high accuracy biomedical applications. View Full-Text
Keywords: optical feedback interferometry; biosensors; vibrometry; flowmetry; biophotonics; metrology optical feedback interferometry; biosensors; vibrometry; flowmetry; biophotonics; metrology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Perchoux, J.; Quotb, A.; Atashkhooei, R.; Azcona, F.J.; Ramírez-Miquet, E.E.; Bernal, O.; Jha, A.; Luna-Arriaga, A.; Yanez, C.; Caum, J.; Bosch, T.; Royo, S. Current Developments on Optical Feedback Interferometry as an All-Optical Sensor for Biomedical Applications. Sensors 2016, 16, 694.

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