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Sensors 2016, 16(5), 630; doi:10.3390/s16050630

Nitrogen-Doped Carbon Dots as A New Substrate for Sensitive Glucose Determination

State Key Laboratory of Coordination Chemistry, Department of Polymer Science & Engineering, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210023, China
Department of Polymer Science & Engineering, Nanjing University, Nanjing 210023, China
Author to whom correspondence should be addressed.
Academic Editors: Giovanni Sparacino, Andrea Facchinetti and J. Hans DeVries
Received: 15 March 2016 / Revised: 15 April 2016 / Accepted: 21 April 2016 / Published: 4 May 2016
(This article belongs to the Special Issue Glucose Sensors: Revolution in Diabetes Management 2016)
View Full-Text   |   Download PDF [2370 KB, uploaded 4 May 2016]   |  


Nitrogen-doped carbon dots are introduced as a novel substrate suitable for enzyme immobilization in electrochemical detection metods. Nitrogen-doped carbon dots are easily synthesised from polyacrylamide in just one step. With the help of the amino group on chitosan, glucose oxidase is immobilized on nitrogen-doped carbon dots-modified carbon glassy electrodes by amino-carboxyl reactions. The nitrogen-induced charge delocalization at nitrogen-doped carbon dots can enhance the electrocatalytic activity toward the reduction of O2. The specific amino-carboxyl reaction provides strong and stable immobilization of GOx on electrodes. The developed biosensor responds efficiently to the presence of glucose in serum samples over the concentration range from 1 to 12 mM with a detection limit of 0.25 mM. This novel biosensor has good reproducibility and stability, and is highly selective for glucose determination under physiological conditions. These results indicate that N-doped quantum dots represent a novel candidate material for the construction of electrochemical biosensors. View Full-Text
Keywords: nitrogen-doped carbon dot; glucose oxidase; enzyme immobilization; biosensor; electrochemical detection nitrogen-doped carbon dot; glucose oxidase; enzyme immobilization; biosensor; electrochemical detection

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ji, H.; Zhou, F.; Gu, J.; Shu, C.; Xi, K.; Jia, X. Nitrogen-Doped Carbon Dots as A New Substrate for Sensitive Glucose Determination. Sensors 2016, 16, 630.

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