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Sensors 2016, 16(5), 630; doi:10.3390/s16050630

Nitrogen-Doped Carbon Dots as A New Substrate for Sensitive Glucose Determination

1
State Key Laboratory of Coordination Chemistry, Department of Polymer Science & Engineering, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210023, China
2
Department of Polymer Science & Engineering, Nanjing University, Nanjing 210023, China
*
Author to whom correspondence should be addressed.
Academic Editors: Giovanni Sparacino, Andrea Facchinetti and J. Hans DeVries
Received: 15 March 2016 / Revised: 15 April 2016 / Accepted: 21 April 2016 / Published: 4 May 2016
(This article belongs to the Special Issue Glucose Sensors: Revolution in Diabetes Management 2016)
View Full-Text   |   Download PDF [2370 KB, uploaded 4 May 2016]   |  

Abstract

Nitrogen-doped carbon dots are introduced as a novel substrate suitable for enzyme immobilization in electrochemical detection metods. Nitrogen-doped carbon dots are easily synthesised from polyacrylamide in just one step. With the help of the amino group on chitosan, glucose oxidase is immobilized on nitrogen-doped carbon dots-modified carbon glassy electrodes by amino-carboxyl reactions. The nitrogen-induced charge delocalization at nitrogen-doped carbon dots can enhance the electrocatalytic activity toward the reduction of O2. The specific amino-carboxyl reaction provides strong and stable immobilization of GOx on electrodes. The developed biosensor responds efficiently to the presence of glucose in serum samples over the concentration range from 1 to 12 mM with a detection limit of 0.25 mM. This novel biosensor has good reproducibility and stability, and is highly selective for glucose determination under physiological conditions. These results indicate that N-doped quantum dots represent a novel candidate material for the construction of electrochemical biosensors. View Full-Text
Keywords: nitrogen-doped carbon dot; glucose oxidase; enzyme immobilization; biosensor; electrochemical detection nitrogen-doped carbon dot; glucose oxidase; enzyme immobilization; biosensor; electrochemical detection
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Ji, H.; Zhou, F.; Gu, J.; Shu, C.; Xi, K.; Jia, X. Nitrogen-Doped Carbon Dots as A New Substrate for Sensitive Glucose Determination. Sensors 2016, 16, 630.

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