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Sensors 2016, 16(4), 483; doi:10.3390/s16040483

Development of a Microforce Sensor and Its Array Platform for Robotic Cell Microinjection Force Measurement

Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen 361005, China
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Author to whom correspondence should be addressed.
Academic Editor: I-Ming Hsing
Received: 14 February 2016 / Revised: 15 March 2016 / Accepted: 17 March 2016 / Published: 6 April 2016
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [5580 KB, uploaded 6 April 2016]   |  

Abstract

Robot-assisted cell microinjection, which is precise and can enable a high throughput, is attracting interest from researchers. Conventional probe-type cell microforce sensors have some real-time injection force measurement limitations, which prevent their integration in a cell microinjection robot. In this paper, a novel supported-beam based cell micro-force sensor with a piezoelectric polyvinylidine fluoride film used as the sensing element is described, which was designed to solve the real-time force-sensing problem during a robotic microinjection manipulation, and theoretical mechanical and electrical models of the sensor function are derived. Furthermore, an array based cell-holding device with a trapezoidal microstructure is micro-fabricated, which serves to improve the force sensing speed and cell manipulation rates. Tests confirmed that the sensor showed good repeatability and a linearity of 1.82%. Finally, robot-assisted zebrafish embryo microinjection experiments were conducted. These results demonstrated the effectiveness of the sensor working with the robotic cell manipulation system. Moreover, the sensing structure, theoretical model, and fabrication method established in this study are not scale dependent. Smaller cells, e.g., mouse oocytes, could also be manipulated with this approach. View Full-Text
Keywords: cell-holding device; cellular force sensor; force measurement; microinjection; micromanipulation; PVDF film cell-holding device; cellular force sensor; force measurement; microinjection; micromanipulation; PVDF film
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xie, Y.; Zhou, Y.; Lin, Y.; Wang, L.; Xi, W. Development of a Microforce Sensor and Its Array Platform for Robotic Cell Microinjection Force Measurement. Sensors 2016, 16, 483.

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