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Sensors 2016, 16(4), 474; doi:10.3390/s16040474

A Portable Low-Power Acquisition System with a Urease Bioelectrochemical Sensor for Potentiometric Detection of Urea Concentrations

1
Instrument System and Chip Group, Department of Electric Engineering, National Cheng Kung University, Tainan 70101, Taiwan
2
Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
3
Biotechnology and Biochemical Engineering Group, Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan
4
Department of Computer Science and Information Engineering, Nan Hua University, Chiayi 62249, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Alexander Star
Received: 15 December 2015 / Revised: 29 March 2016 / Accepted: 30 March 2016 / Published: 2 April 2016
(This article belongs to the Section Biosensors)
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Abstract

This paper presents a portable low-power battery-driven bioelectrochemical signal acquisition system for urea detection. The proposed design has several advantages, including high performance, low cost, low-power consumption, and high portability. A LT1789-1 low-supply-voltage instrumentation amplifier (IA) was used to measure and amplify the open-circuit potential (OCP) between the working and reference electrodes. An MSP430 micro-controller was programmed to process and transduce the signals to the custom-developed software by ZigBee RF module in wireless mode and UART in able mode. The immobilized urease sensor was prepared by embedding urease into the polymer (aniline-co-o-phenylenediamine) polymeric matrix and then coating/depositing it onto a MEMS-fabricated Au working electrode. The linear correlation established between the urea concentration and the potentiometric change is in the urea concentrations range of 3.16 × 10−4 to 3.16 × 10−2 M with a sensitivity of 31.12 mV/log [M] and a precision of 0.995 (R2 = 0.995). This portable device not only detects urea concentrations, but can also operate continuously with a 3.7 V rechargeab-le lithium-ion battery (500 mA·h) for at least four days. Accordingly, its use is feasible and even promising for home-care applications. View Full-Text
Keywords: portable; battery-driven; bioelectrochemical signal acquisition; urea; potentiometric; immobilized urease; MEMS portable; battery-driven; bioelectrochemical signal acquisition; urea; potentiometric; immobilized urease; MEMS
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ma, W.-J.; Luo, C.-H.; Lin, J.-L.; Chou, S.-H.; Chen, P.-H.; Syu, M.-J.; Kuo, S.-H.; Lai, S.-C. A Portable Low-Power Acquisition System with a Urease Bioelectrochemical Sensor for Potentiometric Detection of Urea Concentrations. Sensors 2016, 16, 474.

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