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Sensors 2016, 16(12), 2178; doi:10.3390/s16122178

Label-Free Aptasensors for the Detection of Mycotoxins

1
BAE Laboratory, Université de Perpignan Via Domitia, 52 Avenue Paul Alduy, Perpignan 66860, France
2
Ecole Nationale Supérieure de Biotechnologie, Constantine 25100, Algeria
3
Technological Chemistry Department, Federal University of Maranhão, CCET/UFMA, Av. Portugueses, Cidade Universitária do Canga, 65080-040 São Luis, Brazil
4
Interdisciplinary Research Centre in Biomedical Materials (IRCBM) COMSATS Institute of Information Technology (CIIT), Lahore 54000, Pakistan
*
Authors to whom correspondence should be addressed.
Academic Editor: Beate Strehlitz
Received: 31 October 2016 / Revised: 8 December 2016 / Accepted: 14 December 2016 / Published: 18 December 2016
(This article belongs to the Special Issue Aptasensors 2016)
View Full-Text   |   Download PDF [2566 KB, uploaded 20 December 2016]   |  

Abstract

Various methodologies have been reported in the literature for the qualitative and quantitative monitoring of mycotoxins in food and feed samples. Based on their enhanced specificity, selectivity and versatility, bio-affinity assays have inspired many researchers to develop sensors by exploring bio-recognition phenomena. However, a significant problem in the fabrication of these devices is that most of the biomolecules do not generate an easily measurable signal upon binding to the target analytes, and signal-generating labels are required to perform the measurements. In this context, aptamers have been emerged as a potential and attractive bio-recognition element to design label-free aptasensors for various target analytes. Contrary to other bioreceptor-based approaches, the aptamer-based assays rely on antigen binding-induced conformational changes or oligomerization states rather than binding-assisted changes in adsorbed mass or charge. This review will focus on current designs in label-free conformational switchable design strategies, with a particular focus on applications in the detection of mycotoxins. View Full-Text
Keywords: aptamer; label free detection; mycotoxins; conformational changes; current trends aptamer; label free detection; mycotoxins; conformational changes; current trends
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Rhouati, A.; Catanante, G.; Nunes, G.; Hayat, A.; Marty, J.-L. Label-Free Aptasensors for the Detection of Mycotoxins. Sensors 2016, 16, 2178.

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