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Sensors 2016, 16(10), 1665; doi:10.3390/s16101665

One Binder to Bind Them All

Siemens Healthcare GmbH, Strategy and Innovation, Technology Center, In-Vitro DX & Bioscience, Günther-Scharowsky-Str. 1, 91058 Erlangen, Germany
Academic Editor: Franz L. Dickert
Received: 20 July 2016 / Revised: 25 September 2016 / Accepted: 4 October 2016 / Published: 10 October 2016
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Abstract

High quality binders, such as antibodies, are of critical importance for chemical sensing applications. With synthetic alternatives, such as molecularly imprinted polymers (MIPs), less sensor development time and higher stability of the binder can be achieved. In this feature paper, I will discuss the impact of synthetic binders from an industrial perspective and I will challenge the molecular imprinting community on the next step to leapfrog the current status quo of MIPs for (bio)sensing. Equally important, but often neglected as an effective chemical sensor, is a good match of transducer and MIP coating for a respective application. To demonstrate an application-driven development, a biosensing use case with surface-imprinted layers on piezoacoustic sensors is reported. Depending on the electrode pattern for the transducer, the strong mechanical coupling of the analyte with the MIP layer coated device allows the adoption of the sensitivity from cell mass to cell viability with complete reversibility. View Full-Text
Keywords: sensor; molecularly imprinted polymers; receptor; binder; healthcare; environment; life science; cells; quartz crystal microbalance; lithography; aptamers sensor; molecularly imprinted polymers; receptor; binder; healthcare; environment; life science; cells; quartz crystal microbalance; lithography; aptamers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hayden, O. One Binder to Bind Them All. Sensors 2016, 16, 1665.

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