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Sensors 2016, 16(10), 1581; doi:10.3390/s16101581

A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor

1
Department of Electronics and Information Engineering, Korea University, Sejong 30019, Korea
2
Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA
3
Maritime Safety Research Division, Korea Research Institute of Ships and Ocean Engineering, Daejeon 34103, Korea
4
Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Korea
*
Authors to whom correspondence should be addressed.
Academic Editors: Giovanni Sparacino, Andrea Facchinetti and J. Hans DeVries
Received: 4 July 2016 / Revised: 13 September 2016 / Accepted: 21 September 2016 / Published: 24 September 2016
(This article belongs to the Special Issue Glucose Sensors: Revolution in Diabetes Management 2016)
View Full-Text   |   Download PDF [1828 KB, uploaded 24 September 2016]   |  

Abstract

The incidence of diabetes is continually increasing, and by 2030, it is expected to have increased by 69% and 20% in underdeveloped and developed countries, respectively. Therefore, glucose sensors are likely to remain in high demand in medical device markets. For the current study, we developed a needle-type bio-layer interference (BLI) sensor that can continuously monitor glucose levels. Using dialysis procedures, we were able to obtain hypoglycemic samples from commercial human serum. These dialysis-derived samples, alongside samples of normal human serum were used to evaluate the utility of the sensor for the detection of the clinical interest range of glucose concentrations (70–200 mg/dL), revealing high system performance for a wide glycemic state range (45–500 mg/dL). Reversibility and reproducibility were also tested over a range of time spans. Combined with existing BLI system technology, this sensor holds great promise for use as a wearable online continuous glucose monitoring system for patients in a hospital setting. View Full-Text
Keywords: continuous glucose monitoring; competitive assay; glucose dialysis method; bio-layer interferometry; needle-type sensor continuous glucose monitoring; competitive assay; glucose dialysis method; bio-layer interferometry; needle-type sensor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Seo, D.; Paek, S.-H.; Oh, S.; Seo, S.; Paek, S.-H. A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor. Sensors 2016, 16, 1581.

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