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Sensors 2016, 16(1), 109; doi:10.3390/s16010109

Reduced Graphene Oxide Modified the Interdigitated Chain Electrode for an Insulin Sensor

Department of Biomedical Engineering, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea
Gachon Advanced Institute for Health Science & Technology, Gachon University, 155 Get-Pearl-ro, Yeonsu-gu, Incheon 21999, Korea
Author to whom correspondence should be addressed.
Academic Editor: Gregory Schneider
Received: 28 November 2015 / Revised: 12 January 2016 / Accepted: 13 January 2016 / Published: 15 January 2016
(This article belongs to the Special Issue Graphene and 2D Material Bionanosensors: Chemistry Matters)
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Insulin is a key regulator in glucose homeostasis and its deficiency or alternations in the human body causes various types of diabetic disorders. In this paper, we present the development of a reduced graphene oxide (rGO) modified interdigitated chain electrode (ICE) for direct capacitive detection of insulin. The impedance properties of rGO-ICE were characterized by equivalent circuit modeling. After an electrochemical deposition of rGO on ICE, the electrode was modified with self-assembled monolayers and insulin antibodies in order to achieve insulin binding reactions. The impedance spectra and capacitances were measured with respect to the concentrations of insulin and the capacitance change (ΔC) was analyzed to quantify insulin concentration. The antibody immobilized electrode showed an increment of ΔC according to the insulin concentration in human serum ranging from 1 ng/mL to 10 µg/mL. The proposed sensor is feasible for label-free and real-time measuring of the biomarker and for point-of-care diagnosis. View Full-Text
Keywords: graphene oxide; interdigitated electrode; impedance spectroscopy; capacitive biosensor; insulin graphene oxide; interdigitated electrode; impedance spectroscopy; capacitive biosensor; insulin

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yagati, A.K.; Park, J.; Cho, S. Reduced Graphene Oxide Modified the Interdigitated Chain Electrode for an Insulin Sensor. Sensors 2016, 16, 109.

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