Next Article in Journal
Drivers’ Visual Behavior-Guided RRT Motion Planner for Autonomous On-Road Driving
Next Article in Special Issue
Graphene: The Missing Piece for Cancer Diagnosis?
Previous Article in Journal
On Connected Target k-Coverage in Heterogeneous Wireless Sensor Networks
Previous Article in Special Issue
Studies of Reduced Graphene Oxide and Graphite Oxide in the Aspect of Their Possible Application in Gas Sensors
Article Menu

Export Article

Open AccessArticle
Sensors 2016, 16(1), 109; doi:10.3390/s16010109

Reduced Graphene Oxide Modified the Interdigitated Chain Electrode for an Insulin Sensor

1
Department of Biomedical Engineering, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea
2
Gachon Advanced Institute for Health Science & Technology, Gachon University, 155 Get-Pearl-ro, Yeonsu-gu, Incheon 21999, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Gregory Schneider
Received: 28 November 2015 / Revised: 12 January 2016 / Accepted: 13 January 2016 / Published: 15 January 2016
(This article belongs to the Special Issue Graphene and 2D Material Bionanosensors: Chemistry Matters)
View Full-Text   |   Download PDF [2136 KB, uploaded 15 January 2016]   |  

Abstract

Insulin is a key regulator in glucose homeostasis and its deficiency or alternations in the human body causes various types of diabetic disorders. In this paper, we present the development of a reduced graphene oxide (rGO) modified interdigitated chain electrode (ICE) for direct capacitive detection of insulin. The impedance properties of rGO-ICE were characterized by equivalent circuit modeling. After an electrochemical deposition of rGO on ICE, the electrode was modified with self-assembled monolayers and insulin antibodies in order to achieve insulin binding reactions. The impedance spectra and capacitances were measured with respect to the concentrations of insulin and the capacitance change (ΔC) was analyzed to quantify insulin concentration. The antibody immobilized electrode showed an increment of ΔC according to the insulin concentration in human serum ranging from 1 ng/mL to 10 µg/mL. The proposed sensor is feasible for label-free and real-time measuring of the biomarker and for point-of-care diagnosis. View Full-Text
Keywords: graphene oxide; interdigitated electrode; impedance spectroscopy; capacitive biosensor; insulin graphene oxide; interdigitated electrode; impedance spectroscopy; capacitive biosensor; insulin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yagati, A.K.; Park, J.; Cho, S. Reduced Graphene Oxide Modified the Interdigitated Chain Electrode for an Insulin Sensor. Sensors 2016, 16, 109.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top