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Sensors 2015, 15(8), 19021-19046; doi:10.3390/s150819021

Raman Spectroscopy of Optically Trapped Single Biological Micro-Particles

U.S. Army Research Laboratory, 2800 Powder Mill Road, Adelphi, MD 20783, USA
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Author to whom correspondence should be addressed.
Academic Editor: Stephen Holler
Received: 30 June 2015 / Revised: 30 June 2015 / Accepted: 27 July 2015 / Published: 4 August 2015
(This article belongs to the Special Issue Label-Free Sensing)
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Abstract

The combination of optical trapping with Raman spectroscopy provides a powerful method for the study, characterization, and identification of biological micro-particles. In essence, optical trapping helps to overcome the limitation imposed by the relative inefficiency of the Raman scattering process. This allows Raman spectroscopy to be applied to individual biological particles in air and in liquid, providing the potential for particle identification with high specificity, longitudinal studies of changes in particle composition, and characterization of the heterogeneity of individual particles in a population. In this review, we introduce the techniques used to integrate Raman spectroscopy with optical trapping in order to study individual biological particles in liquid and air. We then provide an overview of some of the most promising applications of this technique, highlighting the unique types of measurements enabled by the combination of Raman spectroscopy with optical trapping. Finally, we present a brief discussion of future research directions in the field. View Full-Text
Keywords: optical trapping; Raman spectroscopy; bioaerosols optical trapping; Raman spectroscopy; bioaerosols
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Redding, B.; Schwab, M.J.; Pan, Y.-L. Raman Spectroscopy of Optically Trapped Single Biological Micro-Particles. Sensors 2015, 15, 19021-19046.

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