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Sensors 2015, 15(7), 17300-17312; doi:10.3390/s150717300

Design and Optimization of SiON Ring Resonator-Based Biosensors for Aflatoxin M1 Detection

1
Nanoscience Laboratory, Department of Physics, University of Trento, Via Sommarive 14, Povo (TN) 38123, Italy
2
LaBSSAH, Fondazione Bruno Kessler, Via Sommarive 18, Povo (TN) 38123, Italy
3
Centre for Materials and Microsystems, Fondazione Bruno Kessler, Via Sommarive 18, Povo (TN) 38123, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Vittorio M.N. Passaro
Received: 31 May 2015 / Revised: 10 July 2015 / Accepted: 13 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Silicon Based Optical Sensors)
View Full-Text   |   Download PDF [2358 KB, uploaded 16 July 2015]   |  

Abstract

In this article, we designed and studied silicon oxynitride (SiON) microring-based photonic structures for biosensing applications. We designed waveguides, directional couplers, and racetrack resonators in order to measure refractive index changes smaller than 10−6 refractive index units (RIU). We tested various samples with different SiON refractive indexes as well as the waveguide dimensions for selecting the sensor with the best performance. Propagation losses and bending losses have been measured on test structures, along with a complete characterization of the resonator’s performances. Sensitivities and limit of detection (LOD) were also measured using glucose-water solutions and compared with expected results from simulations. Finally, we functionalized the resonator and performed sensing experiments with Aflatoxin M1 (AFM1). We were able to detect the binding of aflatoxin for concentrations as low as 12.5 nm. The results open up the path for designing cost-effective biosensors for a fast and reliable sensitive analysis of AFM1 in milk. View Full-Text
Keywords: Whispering Gallery Mode; ring resonator; aflatoxin; waveguide; limit of detection; sensitivity; biosensor; label-free Whispering Gallery Mode; ring resonator; aflatoxin; waveguide; limit of detection; sensitivity; biosensor; label-free
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Guider, R.; Gandolfi, D.; Chalyan, T.; Pasquardini, L.; Samusenko, A.; Pucker, G.; Pederzolli, C.; Pavesi, L. Design and Optimization of SiON Ring Resonator-Based Biosensors for Aflatoxin M1 Detection. Sensors 2015, 15, 17300-17312.

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