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Sensors 2015, 15(6), 12983-12998; doi:10.3390/s150612983

Magnetic-Particle-Sensing Based Diagnostic Protocols and Applications

1
Electronics-Inspired Interdisciplinary Research Institute (EIIRIS), Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku, Toyohashi, Aichi 441-8580, Japan
2
Research Promotion Center, The University of Electro-Communications, 1-5-1 Chofugaoka Chofu, Tokyo 182-8585, Japan
3
Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku, Toyohashi, Aichi 441-8580, Japan
4
Department of Engineering Science, University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Shinya Maenosono
Received: 16 April 2015 / Revised: 18 May 2015 / Accepted: 19 May 2015 / Published: 4 June 2015
(This article belongs to the Special Issue Inorganic Nanoparticles as Biomedical Probes)

Abstract

Magnetic particle-labeled biomaterial detection has attracted much attention in recent years for a number of reasons; easy manipulation by external magnetic fields, easy functionalization of the surface, and large surface-to-volume ratio, to name but a few. In this review, we report on our recent investigations into the detection of nano-sized magnetic particles. First, the detection by Hall magnetic sensor with lock-in amplifier and alternative magnetic field is summarized. Then, our approach to detect sub-200 nm diameter target magnetic particles via relatively large micoro-sized “columnar particles” by optical microscopy is described. Subsequently, we summarize magnetic particle detection based on optical techniques; one method is based on the scattering of the magnetically-assembled nano-sized magnetic bead chain in rotating magnetic fields and the other one is based on the reflection of magnetic target particles and porous silicon. Finally, we report recent works with reference to more familiar industrial products (such as smartphone-based medical diagnosis systems and magnetic removal of unspecific-binded nano-sized particles, or “magnetic washing”). View Full-Text
Keywords: magnetic particles; medical diagnosis; magnetic sensor; self-assembly; porous silicon magnetic particles; medical diagnosis; magnetic sensor; self-assembly; porous silicon
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Takamura, T.; Ko, P.J.; Sharma, J.; Yukino, R.; Ishizawa, S.; Sandhu, A. Magnetic-Particle-Sensing Based Diagnostic Protocols and Applications. Sensors 2015, 15, 12983-12998.

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