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Sensors 2015, 15(6), 12891-12905; doi:10.3390/s150612891

Colorimetric-Based Detection of TNT Explosives Using Functionalized Silica Nanoparticles

1
Electrical Engineering Division, Department of Engineering, University of Cambridge, 9 JJ Thomson Avenue, Cambridge CB3 0FA, UK
2
Institute of Nano Electronic Engineering (INEE), Universiti Malaysia Perlis (UniMAP), Lot 106, 108 & 110, Tingkat 1, Block A, Taman Pertiwi Indah, Jalan Kangar-Alor Setar, Seriab 01000 Kangar, Perlis, Malaysia
3
Schlumberger Cambridge Research, High Cross, Madingley Road, Cambridge CB3 0EL, UK
4
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Sipailou 2, Nanjing 210096, China
*
Author to whom correspondence should be addressed.
Academic Editor: Michael G. Weller
Received: 18 March 2015 / Revised: 29 May 2015 / Accepted: 1 June 2015 / Published: 3 June 2015
(This article belongs to the Special Issue Chemo- and Biosensors for Security and Defense)
View Full-Text   |   Download PDF [1649 KB, uploaded 3 June 2015]   |  

Abstract

This proof-of-concept study proposes a novel sensing mechanism for selective and label-free detection of 2,4,6-trinitrotoluene (TNT). It is realized by surface chemistry functionalization of silica nanoparticles (NPs) with 3-aminopropyl-triethoxysilane (APTES). The primary amine anchored to the surface of the silica nanoparticles (SiO2-NH2) acts as a capturing probe for TNT target binding to form Meisenheimer amine–TNT complexes. A colorimetric change of the self-assembled (SAM) NP samples from the initial green of a SiO2-NH2 nanoparticle film towards red was observed after successful attachment of TNT, which was confirmed as a result of the increased separation between the nanoparticles. The shift in the peak wavelength of the reflected light normal to the film surface and the associated change of the peak width were measured, and a merit function taking into account their combined effect was proposed for the detection of TNT concentrations from 10−12 to 10−4 molar. The selectivity of our sensing approach is confirmed by using TNT-bound nanoparticles incubated in AptamerX, with 2,4-dinitrotoluene (DNT) and toluene used as control and baseline, respectively. Our results show the repeatable systematic color change with the TNT concentration and the possibility to develop a robust, easy-to-use, and low-cost TNT detection method for performing a sensitive, reliable, and semi-quantitative detection in a wide detection range. View Full-Text
Keywords: explosives; functionalized nanoparticles; colorimetric; label-free; self-assembly film; aptamer explosives; functionalized nanoparticles; colorimetric; label-free; self-assembly film; aptamer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Idros, N.; Ho, M.Y.; Pivnenko, M.; Qasim, M.M.; Xu, H.; Gu, Z.; Chu, D. Colorimetric-Based Detection of TNT Explosives Using Functionalized Silica Nanoparticles. Sensors 2015, 15, 12891-12905.

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