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Sensors 2015, 15(12), 31558-31565; doi:10.3390/s151229877

Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers

1
State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou 310027, Zhejiang, China
2
CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China
*
Author to whom correspondence should be addressed.
Academic Editor: Sandeep Kumar Vashist
Received: 4 November 2015 / Revised: 5 December 2015 / Accepted: 11 December 2015 / Published: 15 December 2015
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [586 KB, uploaded 15 December 2015]   |  

Abstract

We report ultrasensitive and highly selective detection of testosterone based on microring resonance sensor using molecularly imprinted polymers (MIP). A silicon-on-insulator (SOI) micoring resonator was modified by MIP films (MIPs) on a surface. The MIPs was synthesized by thermopolymerization using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. The concentration of detected testosterone varies from 0.05 ng/mL to 10 ng/mL. The detection limit reaches 48.7 pg/mL. Ultrahigh sensitivity, good specificity and reproducibility have been demonstrated, indicating the great potential of making a cost effective and easy to operate lab-on-Chip and down scaling micro-fluidics devices in biosensing. View Full-Text
Keywords: Microring resonator; Molecularly imprinted polymers; Testosterone Microring resonator; Molecularly imprinted polymers; Testosterone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chen, Y.; Liu, Y.; Shen, X.; Chang, Z.; Tang, L.; Dong, W.-F.; Li, M.; He, J.-J. Ultrasensitive Detection of Testosterone Using Microring Resonator with Molecularly Imprinted Polymers. Sensors 2015, 15, 31558-31565.

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