Next Article in Journal
Pattern Switchable Antenna System Using Inkjet-Printed Directional Bow-Tie for Bi-Direction Sensing Applications
Next Article in Special Issue
Mechanical Characterization of Hybrid Vesicles Based on Linear Poly(Dimethylsiloxane-b-Ethylene Oxide) and Poly(Butadiene-b-Ethylene Oxide) Block Copolymers
Previous Article in Journal
Adaptive Environmental Source Localization and Tracking with Unknown Permittivity and Path Loss Coefficients
Previous Article in Special Issue
Enhanced Viability of Endothelial Colony Forming Cells in Fibrin Microbeads for Sensor Vascularization
Article Menu

Export Article

Open AccessReview
Sensors 2015, 15(12), 31142-31170; doi:10.3390/s151229848

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

1
International Clinical Research Center (ICRC), Integrated Center of Cellular Therapy and Regenerative Medicine (ICCT), St. Anne’s University Hospital, Brno 656 91, Czech Republic
2
Center for Biomedical Research, University of Algarve, Faro 8005-139, Portugal
3
Tissue Engineering Unit, Università Campus Bio-Medico di Roma, Rome 00128, Italy
4
Department of Biomaterials Science, University of Turku, Turku 20014, Finland
*
Authors to whom correspondence should be addressed.
Academic Editor: Sandeep Kumar Vashist
Received: 22 September 2015 / Revised: 16 November 2015 / Accepted: 4 December 2015 / Published: 10 December 2015
(This article belongs to the Special Issue Novel Biomaterials and Sensors for Tissue Engineering)
View Full-Text   |   Download PDF [549 KB, uploaded 10 December 2015]   |  

Abstract

Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called “organ-on-a-chip” technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field. View Full-Text
Keywords: microfluidics; BioMEMs; organ-on-a-chip; body-on-a-chip; tissue engineering microfluidics; BioMEMs; organ-on-a-chip; body-on-a-chip; tissue engineering
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Perestrelo, A.R.; Águas, A.C.P.; Rainer, A.; Forte, G. Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering. Sensors 2015, 15, 31142-31170.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top