Liver Cancer Detection by a Simple, Inexpensive and Effective Immunosensor with Zinc Oxide Nanoparticles
AbstractRegular monitoring of blood α-fetoprotein (AFP) and/or carcino-embryonic antigen (CEA) levels is important for the routine screening of liver cancer. However, AFP and CEA have a much lower specificity than des-γ-carboxyprothrombin (DCP) to detect liver cancer. Therefore, the study reported here was designed, to develop a screen-printed DCP immunosensor incorporating zinc oxide nanoparticles, for accurate determination of DCP. The designed immunosensor shows low detection limits for the detection of DCP: 0.440 ng/mL (based on impedance measurement), 0.081 ng/mL (based on real part of impedance measurement) and 0.078 ng/mL (based on imaginary part of impedance measurement), within the range of 3.125 ng/mL to 2000 ng/mL. In addition, there was little interference to DCP determination by molecules such as Na+, K+, Ca2+, Cl−, glucose, urea, and uric acid. It is therefore concluded that the DCP immunosensor developed and reported here is simple, inexpensive and effective, and shows promise in the rapid screening of early-stage liver cancer at home with a point-of-care approach. View Full-Text
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Ching, C.T.-S.; van Hieu, N.; Cheng, T.-Y.; Fu, L.-S.; Sun, T.-P.; Liu, M.-Y.; Huang, S.-H.; Yao, Y.-D. Liver Cancer Detection by a Simple, Inexpensive and Effective Immunosensor with Zinc Oxide Nanoparticles. Sensors 2015, 15, 29408-29418.
Ching CT-S, van Hieu N, Cheng T-Y, Fu L-S, Sun T-P, Liu M-Y, Huang S-H, Yao Y-D. Liver Cancer Detection by a Simple, Inexpensive and Effective Immunosensor with Zinc Oxide Nanoparticles. Sensors. 2015; 15(11):29408-29418.Chicago/Turabian Style
Ching, Congo T.-S.; van Hieu, Nguyen; Cheng, Teng-Yun; Fu, Lin-Shien; Sun, Tai-Ping; Liu, Ming-Yen; Huang, Su-Hua; Yao, Yan-Dong. 2015. "Liver Cancer Detection by a Simple, Inexpensive and Effective Immunosensor with Zinc Oxide Nanoparticles." Sensors 15, no. 11: 29408-29418.