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Sensors 2014, 14(10), 19162-19175; doi:10.3390/s141019162

HPV Genotyping 9G Membrane Test: A Point-of-Care Diagnostic Platform

1,†
,
2,†
,
3,†
and
2,†,*
1
Biometrix Technology, Inc. 202 BioVenture Plaza, Chuncheon 200-161, Korea
2
Institute for Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 200-702, Korea
3
Department of Pathology, College of Medicine, CHA University, Seongnam 487-801, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 20 August 2014 / Revised: 24 September 2014 / Accepted: 8 October 2014 / Published: 15 October 2014
(This article belongs to the Special Issue Next-Generation Nucleic Acid Sensors)
View Full-Text   |   Download PDF [1911 KB, uploaded 15 October 2014]   |  

Abstract

The results of HPV detection in 550 cervical samples by cervical cytology were compared with the sequencing analysis and HPV genotyping 9G membrane test. The HPV genotyping 9G membrane test can efficiently identify and discriminate five HR-HPV genotypes. The 100% identical results of HPV genotyping 9G membrane tests with the sequencing results in 550 clinical samples ensure its wide clinical applicability. The simple handling steps and the portable scanning device make the HPV genotyping 9G membrane test applicable in point-of-care settings. Moreover, the HPV genotyping 9G membrane test allows one to obtain final results in 30 min at 25 °C by simply loading the hybridization and washing solution and scanning the membranes without any drying steps or special handling. The clinical sensitivity and specificity of the HPV genotyping 9G membrane test was found to be 100%, which is much higher than cervical cytology. View Full-Text
Keywords: HPV; human papillomavirus; genotyping; cervical carcinoma; hybridization; 9G technology; cervical cytology HPV; human papillomavirus; genotyping; cervical carcinoma; hybridization; 9G technology; cervical cytology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Song, K.; Nimse, S.B.; An, H.; Kim, T. HPV Genotyping 9G Membrane Test: A Point-of-Care Diagnostic Platform. Sensors 2014, 14, 19162-19175.

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