Next Article in Journal
Two-Photon Luminescence and Second Harmonic Generation from Gold Micro-Plates
Previous Article in Journal
Monoterpenes Released from Fruit, Plant, and Vegetable Systems
Article Menu

Export Article

Open AccessReview
Sensors 2014, 14(10), 18302-18327; doi:10.3390/s141018302

Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates

1
Department of Life Science, Hanyang University, Seoul 133-791, Korea
2
Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, Korea
3
Institute of Nano Science and Technology, Hanyang University, Seoul 133-791, Korea
*
Author to whom correspondence should be addressed.
Received: 17 July 2014 / Revised: 8 August 2014 / Accepted: 2 September 2014 / Published: 29 September 2014
(This article belongs to the Section Biosensors)
View Full-Text   |   Download PDF [2920 KB, uploaded 29 September 2014]   |  

Abstract

Detection and characterization of cells using aptamers and aptamer-conjugated nanoprobes has evolved a great deal over the past few decades. This evolution has been driven by the easy selection of aptamers via in vitro cell-SELEX, permitting sensitive discrimination between target and normal cells, which includes pathogenic prokaryotic and cancerous eukaryotic cells. Additionally, when the aptamer-based strategies are used in conjunction with nanomaterials, there is the potential for cell targeting and therapeutic effects with improved specificity and sensitivity. Here we review recent advances in aptamer-based nano-conjugates and their applications for detecting cancer cells and pathogenic bacteria. The multidisciplinary research utilized in this field will play an increasingly significant role in clinical medicine and drug discovery. View Full-Text
Keywords: aptamer; cell-SELEX; bacteria; cancer cell; nanoparticle; nanomaterial aptamer; cell-SELEX; bacteria; cancer cell; nanoparticle; nanomaterial
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gedi, V.; Kim, Y.-P. Detection and Characterization of Cancer Cells and Pathogenic Bacteria Using Aptamer-Based Nano-Conjugates. Sensors 2014, 14, 18302-18327.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sensors EISSN 1424-8220 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top