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Stroke Damage Detection Using Classification Trees on Electrical Bioimpedance Cerebral Spectroscopy Measurements
School of Technology and Health, Royal Institute of Technology, Alfred Nobels Allé 10, Huddinge SE-141 52, Sweden
School of Engineering, University of Boras, Allégatan 1, Boras SE-501 90, Sweden
Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg SE-405 30, Sweden
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Hälsovägen 7, Stockholm SE-141 57, Sweden
* Author to whom correspondence should be addressed.
Received: 18 June 2013; in revised form: 31 July 2013 / Accepted: 5 August 2013 / Published: 7 August 2013
Abstract: After cancer and cardio-vascular disease, stroke is the third greatest cause of death worldwide. Given the limitations of the current imaging technologies used for stroke diagnosis, the need for portable non-invasive and less expensive diagnostic tools is crucial. Previous studies have suggested that electrical bioimpedance (EBI) measurements from the head might contain useful clinical information related to changes produced in the cerebral tissue after the onset of stroke. In this study, we recorded 720 EBI Spectroscopy (EBIS) measurements from two different head regions of 18 hemispheres of nine subjects. Three of these subjects had suffered a unilateral haemorrhagic stroke. A number of features based on structural and intrinsic frequency-dependent properties of the cerebral tissue were extracted. These features were then fed into a classification tree. The results show that a full classification of damaged and undamaged cerebral tissue was achieved after three hierarchical classification steps. Lastly, the performance of the classification tree was assessed using Leave-One-Out Cross Validation (LOO-CV). Despite the fact that the results of this study are limited to a small database, and the observations obtained must be verified further with a larger cohort of patients, these findings confirm that EBI measurements contain useful information for assessing on the health of brain tissue after stroke and supports the hypothesis that classification features based on Cole parameters, spectral information and the geometry of EBIS measurements are useful to differentiate between healthy and stroke damaged brain tissue.
Keywords: stroke; electrical bioimpedance spectroscopy; classification tree; cole parameters
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MDPI and ACS Style
Atefi, S.R.; Seoane, F.; Thorlin, T.; Lindecrantz, K. Stroke Damage Detection Using Classification Trees on Electrical Bioimpedance Cerebral Spectroscopy Measurements. Sensors 2013, 13, 10074-10086.
Atefi SR, Seoane F, Thorlin T, Lindecrantz K. Stroke Damage Detection Using Classification Trees on Electrical Bioimpedance Cerebral Spectroscopy Measurements. Sensors. 2013; 13(8):10074-10086.
Atefi, Seyed R.; Seoane, Fernando; Thorlin, Thorleif; Lindecrantz, Kaj. 2013. "Stroke Damage Detection Using Classification Trees on Electrical Bioimpedance Cerebral Spectroscopy Measurements." Sensors 13, no. 8: 10074-10086.