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Sensors 2013, 13(6), 7599-7617; doi:10.3390/s130607599
Article

Two Phase Non-Rigid Multi-Modal Image Registration Using Weber Local Descriptor-Based Similarity Metrics and Normalized Mutual Information

1,2
, 1
, 1,* , 1
 and 3
1 College of Life Science and Technology, Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China, Huazhong University of Science and Technology, Wuhan 430074, China 2 School of Computer and Electronics and Information, Guangxi University, Nanning 530004, China 3 Department of Radiology, Wayne State University, 3990 John R., Detroit, MI 48201, USA
* Author to whom correspondence should be addressed.
Received: 3 April 2013 / Revised: 24 May 2013 / Accepted: 5 June 2013 / Published: 13 June 2013
(This article belongs to the Special Issue Medical & Biological Imaging)
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Abstract

Non-rigid multi-modal image registration plays an important role in medical image processing and analysis. Existing image registration methods based on similarity metrics such as mutual information (MI) and sum of squared differences (SSD) cannot achieve either high registration accuracy or high registration efficiency. To address this problem, we propose a novel two phase non-rigid multi-modal image registration method by combining Weber local descriptor (WLD) based similarity metrics with the normalized mutual information (NMI) using the diffeomorphic free-form deformation (FFD) model. The first phase aims at recovering the large deformation component using the WLD based non-local SSD (wldNSSD) or weighted structural similarity (wldWSSIM). Based on the output of the former phase, the second phase is focused on getting accurate transformation parameters related to the small deformation using the NMI. Extensive experiments on T1, T2 and PD weighted MR images demonstrate that the proposed wldNSSD-NMI or wldWSSIM-NMI method outperforms the registration methods based on the NMI, the conditional mutual information (CMI), the SSD on entropy images (ESSD) and the ESSD-NMI in terms of registration accuracy and computation efficiency.
Keywords: non-rigid multi-modal registration; Weber local descriptor; sum of squared differences; structural similarity; mutual information non-rigid multi-modal registration; Weber local descriptor; sum of squared differences; structural similarity; mutual information
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yang, F.; Ding, M.; Zhang, X.; Wu, Y.; Hu, J. Two Phase Non-Rigid Multi-Modal Image Registration Using Weber Local Descriptor-Based Similarity Metrics and Normalized Mutual Information. Sensors 2013, 13, 7599-7617.

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